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4o67
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4o67 is ON HOLD Authors: Zhang, X., Chen, Z. , Zhang, X.W., Chen, Z.J. Description: Protein structure in ligand bound form) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human cyclic GMP-AMP synthase (cGAS) in complex with GAMP== | |
| + | <StructureSection load='4o67' size='340' side='right'caption='[[4o67]], [[Resolution|resolution]] 2.44Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4o67]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O67 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.444Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o67 OCA], [https://pdbe.org/4o67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o67 RCSB], [https://www.ebi.ac.uk/pdbsum/4o67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o67 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Cyclic GMP-AMP synthase|Cyclic GMP-AMP synthase]] | |
| - | + | *[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen Z]] | ||
| + | [[Category: Chen ZJ]] | ||
| + | [[Category: Zhang X]] | ||
| + | [[Category: Zhang XW]] | ||
Current revision
Human cyclic GMP-AMP synthase (cGAS) in complex with GAMP
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Categories: Homo sapiens | Large Structures | Chen Z | Chen ZJ | Zhang X | Zhang XW
