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4obv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-FMT)== | |
| - | + | <StructureSection load='4obv' size='340' side='right'caption='[[4obv]], [[Resolution|resolution]] 2.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4obv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ruminococcus_gnavus_ATCC_29149 Ruminococcus gnavus ATCC 29149]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OBV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2SU:ALPHA-(FLUOROMETHYL)-D-TRYPTOPHAN'>2SU</scene>, <scene name='pdbligand=3SO:{5-HYDROXY-4-[(1E)-4-(1H-INDOL-3-YL)-3-OXOBUT-1-EN-1-YL]-6-METHYLPYRIDIN-3-YL}METHYL+DIHYDROGEN+PHOSPHATE'>3SO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4obv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4obv OCA], [https://pdbe.org/4obv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4obv RCSB], [https://www.ebi.ac.uk/pdbsum/4obv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4obv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRPDC_RUMGV TRPDC_RUMGV] Catalyzes the decarboxylation of tryptophan to tryptamine. Tryptamine is a neurotransmitter that induces the release of serotonin, which is suggested to modulate gastrointestinal motility. Therefore, the tryptophan decarboxylase from the gut bacteria Ruminococcus gnavus (strain ATCC 29149 / VPI C7-9) may influence host brain and behavior. Has weak activity with tyrosine and phenylalanine.<ref>PMID:25263219</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fraser JS]] | ||
| + | [[Category: Van Benschoten AH]] | ||
Current revision
Ruminococcus gnavus tryptophan decarboxylase RUMGNA_01526 (alpha-FMT)
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