This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4omh
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4omh is ON HOLD Authors: Janke, R., Goerner, C., Hirte, M., Brueck, T., Loll, B. Description: Crystal structure of a diterpene cyclase) |
|||
| (10 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the bacterial diterpene cyclase COTB2 variant F149L== | |
| - | + | <StructureSection load='4omh' size='340' side='right'caption='[[4omh]], [[Resolution|resolution]] 1.64Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4omh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_melanosporofaciens Streptomyces melanosporofaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OMH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4omh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4omh OCA], [https://pdbe.org/4omh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4omh RCSB], [https://www.ebi.ac.uk/pdbsum/4omh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4omh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/COTB2_STRMJ COTB2_STRMJ] Catalyzes the cyclization of the linear isoprenoid intermediate geranylgeranyl diphosphate to tricycclic cyclooctat-9-en-7-ol in the cyclooctatin biosynthesis pathway. Cyclooctatin is a potent inhibitor of lysophospholipase.<ref>PMID:19635410</ref> <ref>PMID:24914964</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces melanosporofaciens]] | ||
| + | [[Category: Brueck T]] | ||
| + | [[Category: Goerner C]] | ||
| + | [[Category: Hirte M]] | ||
| + | [[Category: Janke R]] | ||
| + | [[Category: Loll B]] | ||
Current revision
Crystal structure of the bacterial diterpene cyclase COTB2 variant F149L
| |||||||||||
