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4ons

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{{STRUCTURE_4ons| PDB=4ons | SCENE= }}
 
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===Structural and thermodynamic characterization of cadherin-beta-catenin-alpha-catenin complex formation===
 
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==Function==
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==Structural and thermodynamic characterization of cadherin-beta-catenin-alpha-catenin complex formation==
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[[http://www.uniprot.org/uniprot/CTNA2_MOUSE CTNA2_MOUSE]] May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.<ref>PMID:12089526</ref> <ref>PMID:12123610</ref> <ref>PMID:15034585</ref> [[http://www.uniprot.org/uniprot/CTNB1_MOUSE CTNB1_MOUSE]] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).
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<StructureSection load='4ons' size='340' side='right'caption='[[4ons]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ons]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ONS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ONS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ons FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ons OCA], [https://pdbe.org/4ons PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ons RCSB], [https://www.ebi.ac.uk/pdbsum/4ons PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ons ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CTNA2_MOUSE CTNA2_MOUSE] May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.<ref>PMID:12089526</ref> <ref>PMID:12123610</ref> <ref>PMID:15034585</ref>
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==About this Structure==
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==See Also==
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[[4ons]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ONS OCA].
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*[[Catenin 3D structures|Catenin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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[[Category: Ahlsen, G.]]
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</StructureSection>
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[[Category: Choi, H J.]]
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[[Category: Large Structures]]
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[[Category: Hansen, S D.]]
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[[Category: Mus musculus]]
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[[Category: Pokutta, S.]]
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[[Category: Ahlsen G]]
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[[Category: Weis, W I.]]
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[[Category: Choi H-J]]
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[[Category: Cell adhesion]]
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[[Category: Hansen SD]]
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[[Category: Four helix bundle]]
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[[Category: Pokutta S]]
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[[Category: Weis WI]]

Current revision

Structural and thermodynamic characterization of cadherin-beta-catenin-alpha-catenin complex formation

PDB ID 4ons

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