4pvs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4pvs" [edit=sysop:move=sysop])
Current revision (12:43, 1 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4pvs| PDB=4pvs | SCENE= }}
 
-
===Crystal structure of fully-cleaved human l-asparaginase protein in complex with l-aspartate===
 
-
{{ABSTRACT_PUBMED_22861376}}
 
-
==Function==
+
==Crystal structure of fully-cleaved human l-asparaginase protein in complex with l-aspartate==
-
[[http://www.uniprot.org/uniprot/ASGL1_HUMAN ASGL1_HUMAN]] Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.<ref>PMID:19839645</ref>
+
<StructureSection load='4pvs' size='340' side='right'caption='[[4pvs]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4pvs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gdw 4gdw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PVS FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvs OCA], [https://pdbe.org/4pvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pvs RCSB], [https://www.ebi.ac.uk/pdbsum/4pvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvs ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ASGL1_HUMAN ASGL1_HUMAN] Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.<ref>PMID:19839645</ref>
-
==About this Structure==
+
==See Also==
-
[[4pvs]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4gdw 4gdw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVS OCA].
+
*[[Asparaginase 3D structures|Asparaginase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:022861376</ref><references group="xtra"/><references/>
+
__TOC__
-
[[Category: Lavie, A.]]
+
</StructureSection>
-
[[Category: Nomme, J.]]
+
[[Category: Homo sapiens]]
-
[[Category: Homodimer]]
+
[[Category: Large Structures]]
-
[[Category: Hydrolase]]
+
[[Category: Lavie A]]
-
[[Category: L-asparagine]]
+
[[Category: Nomme J]]
-
[[Category: Ntn enzyme]]
+

Current revision

Crystal structure of fully-cleaved human l-asparaginase protein in complex with l-aspartate

PDB ID 4pvs

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4pvs"
Personal tools