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4q4k

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'''Unreleased structure'''
 
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The entry 4q4k is ON HOLD until Paper Publication
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==Crystal structure of nitronate monooxygenase from Pseudomonas aeruginosa PAO1==
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<StructureSection load='4q4k' size='340' side='right'caption='[[4q4k]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4q4k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q4K FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.44&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4k OCA], [https://pdbe.org/4q4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q4k RCSB], [https://www.ebi.ac.uk/pdbsum/4q4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q4k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NMO_PSEAE NMO_PSEAE] Nitronate monooxygenase that uses molecular oxygen to catalyze the oxidative denitrification of alkyl nitronates. The toxin propionate 3-nitronate (P3N) is the best substrate (and the presumed physiological substrate), but this enzyme is also active on other primary and secondary nitronates such as propyl-1-nitronate, ethylnitronate, pentyl-1-nitronate, butyl-1-nitronate and propyl-2-nitronate (PubMed:25002579). Is likely involved in the degradation of P3N, that allows P.aeruginosa PAO1 to grow on 3-nitropropionate/P3N as the sole nitrogen source (PubMed:20382807). Also functions in the detoxification of P3N, a metabolic poison produced by plants and fungi as a defense mechanism (PubMed:25384477). Cannot oxidize nitroalkanes such as 3-nitropropionate, nitroethane, 1-nitropropane, 1-nitrobutane, 1-nitropentane, or 2-nitropropane (PubMed:25002579).<ref>PMID:20382807</ref> <ref>PMID:25002579</ref> <ref>PMID:25384477</ref>
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Authors: Salvi, F., Agniswamy, J., Gadda, G., Weber, I.T.
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==See Also==
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*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
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Description: Crystal structure of nitronate monooxygenase from Pseudomonas aeruginosa PAO1
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Agniswamy J]]
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[[Category: Gadda G]]
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[[Category: Salvi F]]
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[[Category: Weber IT]]

Current revision

Crystal structure of nitronate monooxygenase from Pseudomonas aeruginosa PAO1

PDB ID 4q4k

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