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4qe8

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==FXR with DM175 and NCoA-2 peptide==
==FXR with DM175 and NCoA-2 peptide==
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<StructureSection load='4qe8' size='340' side='right' caption='[[4qe8]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
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<StructureSection load='4qe8' size='340' side='right'caption='[[4qe8]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qe8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QE8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qe8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QE8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31D:4-({2-[(4-TERT-BUTYLBENZOYL)AMINO]BENZOYL}AMINO)BENZOIC+ACID'>31D</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qe6|4qe6]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=31D:4-({2-[(4-TERT-BUTYLBENZOYL)AMINO]BENZOYL}AMINO)BENZOIC+ACID'>31D</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qe8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qe8 RCSB], [http://www.ebi.ac.uk/pdbsum/4qe8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qe8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe8 OCA], [https://pdbe.org/4qe8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qe8 RCSB], [https://www.ebi.ac.uk/pdbsum/4qe8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qe8 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
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[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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==See Also==
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*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bamberg, K]]
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[[Category: Homo sapiens]]
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[[Category: Dekker, N]]
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[[Category: Large Structures]]
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[[Category: Kudlinzki, D]]
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[[Category: Bamberg K]]
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[[Category: Linhard, V L]]
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[[Category: Dekker N]]
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[[Category: Merk, D]]
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[[Category: Kudlinzki D]]
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[[Category: Nilsson, E]]
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[[Category: Linhard VL]]
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[[Category: Saxena, K]]
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[[Category: Merk D]]
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[[Category: Schubert-Zsilavecz, M]]
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[[Category: Nilsson E]]
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[[Category: Schwalbe, H]]
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[[Category: Saxena K]]
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[[Category: Sreeramulu, S]]
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[[Category: Schubert-Zsilavecz M]]
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[[Category: Wissler, L]]
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[[Category: Schwalbe H]]
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[[Category: Bile acid receptor dna]]
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[[Category: Sreeramulu S]]
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[[Category: Receptor]]
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[[Category: Wissler L]]
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[[Category: Transcription]]
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Current revision

FXR with DM175 and NCoA-2 peptide

PDB ID 4qe8

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