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4qi0

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'''Unreleased structure'''
 
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The entry 4qi0 is ON HOLD until Paper Publication
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==X-ray structure of the ROQ domain from murine Roquin-1==
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<StructureSection load='4qi0' size='340' side='right'caption='[[4qi0]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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Authors: Janowski, R., Schlundt, A., Sattler, M., Niessing, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4qi0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QI0 FirstGlance]. <br>
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Description: X-ray structure of the ROQ domain from murine Roquin-1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qi0 OCA], [https://pdbe.org/4qi0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qi0 RCSB], [https://www.ebi.ac.uk/pdbsum/4qi0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qi0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RC3H1_MOUSE RC3H1_MOUSE] Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (PubMed:23663784). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4/Ox40 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation.<ref>PMID:15917799</ref> <ref>PMID:18172933</ref> <ref>PMID:20412057</ref> <ref>PMID:20639877</ref> <ref>PMID:23663784</ref> <ref>PMID:23583643</ref> <ref>PMID:23583642</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Janowski R]]
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[[Category: Niessing D]]
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[[Category: Sattler M]]
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[[Category: Schlundt A]]

Current revision

X-ray structure of the ROQ domain from murine Roquin-1

PDB ID 4qi0

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