1qo8

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[[Image:1qo8.gif|left|200px]]
[[Image:1qo8.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1qo8 |SIZE=350|CAPTION= <scene name='initialview01'>1qo8</scene>, resolution 2.15&Aring;
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The line below this paragraph, containing "STRUCTURE_1qo8", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Hem+Binding+Site+For+Resdiue+A601'>AC1</scene>, <scene name='pdbsite=AC2:Hem+Binding+Site+For+Resdiue+A602'>AC2</scene>, <scene name='pdbsite=AC3:Hem+Binding+Site+For+Resdiue+A603'>AC3</scene>, <scene name='pdbsite=AC4:Hem+Binding+Site+For+Resdiue+A604'>AC4</scene>, <scene name='pdbsite=AC5:Fad+Binding+Site+For+Resdiue+A605'>AC5</scene>, <scene name='pdbsite=AC6:Hem+Binding+Site+For+Resdiue+D601'>AC6</scene>, <scene name='pdbsite=AC7:Hem+Binding+Site+For+Resdiue+D602'>AC7</scene>, <scene name='pdbsite=AC8:Hem+Binding+Site+For+Residue+D603'>AC8</scene>, <scene name='pdbsite=AC9:Hem+Binding+Site+For+Residue+D604'>AC9</scene> and <scene name='pdbsite=BC1:Fad+Binding+Site+For+Residue+D605'>BC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate_dehydrogenase Succinate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.1 1.3.99.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1qo8| PDB=1qo8 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qo8 OCA], [http://www.ebi.ac.uk/pdbsum/1qo8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qo8 RCSB]</span>
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}}
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'''THE STRUCTURE OF THE OPEN CONFORMATION OF A FLAVOCYTOCHROME C3 FUMARATE REDUCTASE'''
'''THE STRUCTURE OF THE OPEN CONFORMATION OF A FLAVOCYTOCHROME C3 FUMARATE REDUCTASE'''
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[[Category: Hemmings, A M.]]
[[Category: Hemmings, A M.]]
[[Category: Richardson, D J.]]
[[Category: Richardson, D J.]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:30:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:16:37 2008''
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Revision as of 03:30, 3 May 2008

Image:1qo8.gif

Template:STRUCTURE 1qo8

THE STRUCTURE OF THE OPEN CONFORMATION OF A FLAVOCYTOCHROME C3 FUMARATE REDUCTASE


Overview

Fumarate reductases and succinate dehydrogenases play central roles in the metabolism of eukaryotic and prokaryotic cells. A recent medium resolution structure of the Escherichia coli fumarate reductase (Frd) has revealed the overall organization of the membrane-bound complex. Here we present the first high resolution X-ray crystal structure of a water-soluble bacterial fumarate reductase in an open conformation. This structure reveals a mobile domain that modulates substrate access to the active site and provides new insights into the mechanism of this widespread and important family of FAD-containing respiratory proteins.

About this Structure

1QO8 is a Single protein structure of sequence from Shewanella frigidimarina. Full crystallographic information is available from OCA.

Reference

Open conformation of a flavocytochrome c3 fumarate reductase., Bamford V, Dobbin PS, Richardson DJ, Hemmings AM, Nat Struct Biol. 1999 Dec;6(12):1104-7. PMID:10581549 Page seeded by OCA on Sat May 3 06:30:41 2008

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