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4r7e

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'''Unreleased structure'''
 
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The entry 4r7e is ON HOLD until Paper Publication
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==Structure of Bre1 RING domain==
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<StructureSection load='4r7e' size='340' side='right'caption='[[4r7e]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4r7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R7E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.251&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r7e OCA], [https://pdbe.org/4r7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r7e RCSB], [https://www.ebi.ac.uk/pdbsum/4r7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r7e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BRE1_YEAST BRE1_YEAST] E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme RAD6/UBC2. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. Also modulates the formation of double-strand breaks during meiosis.<ref>PMID:12535538</ref> <ref>PMID:12535539</ref> <ref>PMID:12876294</ref> <ref>PMID:15280549</ref> <ref>PMID:15632065</ref>
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Authors: Kumar, P., Wolberger, C.
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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Description: Structure of Bre1 RING domain
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Wolberger, C]]
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__TOC__
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[[Category: Kumar, P]]
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Kumar P]]
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[[Category: Wolberger C]]

Current revision

Structure of Bre1 RING domain

PDB ID 4r7e

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