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4r7x

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==Crystal structure of N-lobe of human ARRDC3(1-180)==
==Crystal structure of N-lobe of human ARRDC3(1-180)==
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<StructureSection load='4r7x' size='340' side='right' caption='[[4r7x]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
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<StructureSection load='4r7x' size='340' side='right'caption='[[4r7x]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r7x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R7X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R7X FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r7v|4r7v]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r7x RCSB], [http://www.ebi.ac.uk/pdbsum/4r7x PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r7x OCA], [https://pdbe.org/4r7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r7x RCSB], [https://www.ebi.ac.uk/pdbsum/4r7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r7x ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/ARRD3_HUMAN ARRD3_HUMAN]
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ARRDC3 is one of six known human alpha-arrestins, and has been implicated in the downregulation of the beta2-adrenergic receptor (beta2AR). ARRDC3 consists of a two-lobed arrestin fold and a C-terminal tail containing two PPYX motifs. In the current model for receptor downregulation by ARRDC3, the arrestin fold portion is thought to bind the receptor, while the PPXY motifs recruit ubiquitin ligases of the NEDD4 family. Here we report the crystal structures of the N-terminal lobe of human ARRDC3 in two conformations, at 1.73 and 2.8 A resolution, respectively. The structures reveal a large electropositive region that is capable of binding phosphate ions of crystallization. Residues within the basic patch were shown to be important for binding to beta2AR, similar to the situation with beta-arrestins. This highlights potential parallels in receptor recognition between alpha- and beta-arrestins.
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Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.,Qi S, O'Hayre M, Gutkind JS, Hurley JH Protein Sci. 2014 Sep 12. doi: 10.1002/pro.2549. PMID:25220262<ref>PMID:25220262</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hurley, J.]]
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[[Category: Homo sapiens]]
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[[Category: Qi, S.]]
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[[Category: Large Structures]]
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[[Category: Arrestin fold]]
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[[Category: Hurley J]]
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[[Category: Beat 2 adrenergic receptor]]
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[[Category: Qi S]]
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[[Category: Gpcr downregulation]]
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[[Category: Protein binding]]
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Current revision

Crystal structure of N-lobe of human ARRDC3(1-180)

PDB ID 4r7x

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