4r8h
From Proteopedia
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==The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein== | ==The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein== | ||
| - | <StructureSection load='4r8h' size='340' side='right' caption='[[4r8h]], [[Resolution|resolution]] 1.46Å' scene=''> | + | <StructureSection load='4r8h' size='340' side='right'caption='[[4r8h]], [[Resolution|resolution]] 1.46Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4r8h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8H OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4r8h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R8H FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SP1:6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL'>SP1</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SP1:6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL'>SP1</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8h OCA], [https://pdbe.org/4r8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r8h RCSB], [https://www.ebi.ac.uk/pdbsum/4r8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r8h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Cann MJ]] |
| - | [[Category: | + | [[Category: Glover LC]] |
| - | [[Category: | + | [[Category: Hodgson DRW]] |
| - | [[Category: | + | [[Category: Korhonen HJ]] |
| - | [[Category: | + | [[Category: McLeish TCB]] |
| - | [[Category: | + | [[Category: Pohl E]] |
| - | [[Category: | + | [[Category: Rodgers TL]] |
| - | [[Category: | + | [[Category: Townsend PD]] |
| - | [[Category: | + | [[Category: Wilson MR]] |
Current revision
The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein
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