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4rmg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Sirt2 in complex with SirReal2 and NAD+== | |
| + | <StructureSection load='4rmg' size='340' side='right'caption='[[4rmg]], [[Resolution|resolution]] 1.88Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4rmg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RMG FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TE:2-[(4,6-DIMETHYLPYRIMIDIN-2-YL)SULFANYL]-N-[5-(NAPHTHALEN-1-YLMETHYL)-1,3-THIAZOL-2-YL]ACETAMIDE'>3TE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rmg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rmg OCA], [https://pdbe.org/4rmg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rmg RCSB], [https://www.ebi.ac.uk/pdbsum/4rmg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rmg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Einsle O]] | ||
| + | [[Category: Gajer M]] | ||
| + | [[Category: Gerhardt S]] | ||
| + | [[Category: Jung M]] | ||
| + | [[Category: Karaman B]] | ||
| + | [[Category: Ladwein KI]] | ||
| + | [[Category: Lehotzky A]] | ||
| + | [[Category: North BJ]] | ||
| + | [[Category: Olah J]] | ||
| + | [[Category: Ovadi J]] | ||
| + | [[Category: Pannek M]] | ||
| + | [[Category: Roessler C]] | ||
| + | [[Category: Rumpf T]] | ||
| + | [[Category: Schiedel M]] | ||
| + | [[Category: Schmidtkunz K]] | ||
| + | [[Category: Schutkowski M]] | ||
| + | [[Category: Sinclair DA]] | ||
| + | [[Category: Sippl W]] | ||
| + | [[Category: Steegborn C]] | ||
Current revision
Human Sirt2 in complex with SirReal2 and NAD+
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Categories: Homo sapiens | Large Structures | Einsle O | Gajer M | Gerhardt S | Jung M | Karaman B | Ladwein KI | Lehotzky A | North BJ | Olah J | Ovadi J | Pannek M | Roessler C | Rumpf T | Schiedel M | Schmidtkunz K | Schutkowski M | Sinclair DA | Sippl W | Steegborn C
