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4rmh

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'''Unreleased structure'''
 
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The entry 4rmh is ON HOLD until Paper Publication
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==Human Sirt2 in complex with SirReal2 and Ac-Lys-H3 peptide==
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<StructureSection load='4rmh' size='340' side='right'caption='[[4rmh]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4rmh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RMH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TE:2-[(4,6-DIMETHYLPYRIMIDIN-2-YL)SULFANYL]-N-[5-(NAPHTHALEN-1-YLMETHYL)-1,3-THIAZOL-2-YL]ACETAMIDE'>3TE</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rmh OCA], [https://pdbe.org/4rmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rmh RCSB], [https://www.ebi.ac.uk/pdbsum/4rmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rmh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref>
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Authors: Rumpf, T., Schiedel, M., Karaman, B., Roessler, C., North, B.J., Lehotzky, A., Olah, J., Ladwein, K.I., Schmidtkunz, K., Gajer, M., Pannek, M., Steegborn, C., Sinclair, D.A., Gerhardt, S., Ovadi, J., Schutkowski, M., Sippl, W., Einsle, O., Jung, M.
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==See Also==
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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Description: Human Sirt2 in complex with SirReal2 and Ac-Lys-H3 peptide
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Schmidtkunz, K]]
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__TOC__
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[[Category: Sinclair, D.A]]
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</StructureSection>
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[[Category: Rumpf, T]]
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[[Category: Homo sapiens]]
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[[Category: Pannek, M]]
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[[Category: Large Structures]]
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[[Category: Roessler, C]]
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[[Category: Einsle O]]
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[[Category: Sippl, W]]
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[[Category: Gajer M]]
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[[Category: Gerhardt, S]]
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[[Category: Gerhardt S]]
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[[Category: Jung, M]]
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[[Category: Jung M]]
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[[Category: Lehotzky, A]]
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[[Category: Karaman B]]
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[[Category: Karaman, B]]
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[[Category: Ladwein KI]]
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[[Category: Steegborn, C]]
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[[Category: Lehotzky A]]
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[[Category: North, B.J]]
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[[Category: North BJ]]
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[[Category: Schutkowski, M]]
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[[Category: Olah J]]
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[[Category: Olah, J]]
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[[Category: Ovadi J]]
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[[Category: Gajer, M]]
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[[Category: Pannek M]]
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[[Category: Ovadi, J]]
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[[Category: Roessler C]]
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[[Category: Schiedel, M]]
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[[Category: Rumpf T]]
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[[Category: Ladwein, K.I]]
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[[Category: Schiedel M]]
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[[Category: Einsle, O]]
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[[Category: Schmidtkunz K]]
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[[Category: Schutkowski M]]
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[[Category: Sinclair DA]]
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[[Category: Sippl W]]
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[[Category: Steegborn C]]

Current revision

Human Sirt2 in complex with SirReal2 and Ac-Lys-H3 peptide

PDB ID 4rmh

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