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4v96

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==The structure of a 1.8 MDa viral genome injection device suggests alternative infection mechanisms==
==The structure of a 1.8 MDa viral genome injection device suggests alternative infection mechanisms==
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<StructureSection load='4v96' size='340' side='right' caption='[[4v96]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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<StructureSection load='4v96' size='340' side='right'caption='[[4v96]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4v96]] is a 78 chain structure. This structure supersedes and combines the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4div 4div] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4diw 4diw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V96 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4v96]] is a 78 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_phage_TP901-1 Lactococcus phage TP901-1]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4div 4div] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4diw 4diw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V96 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uh8|3uh8]], [[3u6x|3u6x]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v96 RCSB], [http://www.ebi.ac.uk/pdbsum/4v96 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v96 OCA], [https://pdbe.org/4v96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v96 RCSB], [https://www.ebi.ac.uk/pdbsum/4v96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v96 ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
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== Function ==
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<div style="background-color:#fffaf0;">
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[https://www.uniprot.org/uniprot/Q9AZ56_9CAUD Q9AZ56_9CAUD]
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== Publication Abstract from PubMed ==
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Phages of the Caudovirales order possess a tail that recognizes the host and ensures genome delivery upon infection. The X-ray structure of the approximately 1.8 MDa host adsorption device (baseplate) from the lactococcal phage TP901-1 shows that the receptor-binding proteins are pointing in the direction of the host, suggesting that this organelle is in a conformation ready for host adhesion. This result is in marked contrast with the lactococcal phage p2 situation, whose baseplate is known to undergo huge conformational changes in the presence of Ca(2+) to reach its active state. In vivo infection experiments confirmed these structural observations by demonstrating that Ca(2+) ions are required for host adhesion among p2-like phages (936-species) but have no influence on TP901-1-like phages (P335-species). These data suggest that these two families rely on diverse adhesion strategies which may lead to different signaling for genome release.
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Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism.,Veesler D, Spinelli S, Mahony J, Lichiere J, Blangy S, Bricogne G, Legrand P, Ortiz-Lombardia M, Campanacci V, van Sinderen D, Cambillau C Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8954-8. Epub 2012 May 18. PMID:22611190<ref>PMID:22611190</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Blangy, S]]
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[[Category: Lactococcus phage TP901-1]]
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[[Category: Bricogne, G]]
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[[Category: Large Structures]]
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[[Category: Cambillau, C]]
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[[Category: Blangy S]]
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[[Category: Campanacci, V]]
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[[Category: Bricogne G]]
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[[Category: Legrand, P]]
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[[Category: Cambillau C]]
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[[Category: Lichiere, J]]
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[[Category: Campanacci V]]
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[[Category: Mahony, J]]
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[[Category: Legrand P]]
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[[Category: Ortiz-Lombardia, M]]
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[[Category: Lichiere J]]
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[[Category: Sinderen, D van]]
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[[Category: Mahony J]]
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[[Category: Spinelli, S]]
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[[Category: Ortiz-Lombardia M]]
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[[Category: Veesler, D]]
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[[Category: Spinelli S]]
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[[Category: Distal tail protein]]
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[[Category: Veesler D]]
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[[Category: Genome injection device]]
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[[Category: Van Sinderen D]]
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[[Category: Host adsorption apparatus]]
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[[Category: Phage baseplate]]
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[[Category: Receptor-binding protein]]
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[[Category: Viral protein]]
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Current revision

The structure of a 1.8 MDa viral genome injection device suggests alternative infection mechanisms

PDB ID 4v96

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