4xrp

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==Structure of the Pnkp1/Rnl/Hen1 RNA repair complex==
==Structure of the Pnkp1/Rnl/Hen1 RNA repair complex==
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<StructureSection load='4xrp' size='340' side='right' caption='[[4xrp]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='4xrp' size='340' side='right'caption='[[4xrp]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xrp]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XRP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XRP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xrp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Capnocytophaga_gingivalis_ATCC_33624 Capnocytophaga gingivalis ATCC 33624]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XRP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xru|4xru]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xrp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xrp RCSB], [http://www.ebi.ac.uk/pdbsum/4xrp PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xrp OCA], [https://pdbe.org/4xrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xrp RCSB], [https://www.ebi.ac.uk/pdbsum/4xrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xrp ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/C2M8N3_CAPGI C2M8N3_CAPGI]
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Ribotoxins cleave essential RNAs for cell killing, and RNA repair neutralizes the damage inflicted by ribotoxins for cell survival. Here we report a new bacterial RNA repair complex that performs RNA repair linked to immunity. This new RNA repair complex is a 270-kDa heterohexamer composed of three proteins-Pnkp1, Rnl and Hen1-that are required to repair ribotoxin-cleaved RNA in vitro. The crystal structure of the complex reveals the molecular architecture of the heterohexamer as two rhomboid-shaped ring structures of Pnkp1-Rnl-Hen1 heterotrimer fused at the Pnkp1 dimer interface. The four active sites required for RNA repair are located on the inner rim of each ring. The architecture and the locations of the active sites of the Pnkp1-Rnl-Hen1 heterohexamer suggest an ordered series of repair reactions at the broken RNA ends that confer immunity to recurrent damage.
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Reconstitution and structure of a bacterial Pnkp1-Rnl-Hen1 RNA repair complex.,Wang P, Selvadurai K, Huang RH Nat Commun. 2015 Apr 17;6:6876. doi: 10.1038/ncomms7876. PMID:25882814<ref>PMID:25882814</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Huang, R H]]
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[[Category: Capnocytophaga gingivalis ATCC 33624]]
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[[Category: Wang, P]]
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[[Category: Large Structures]]
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[[Category: Kinase]]
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[[Category: Huang RH]]
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[[Category: Ligase]]
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[[Category: Wang P]]
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[[Category: Methyltransferase]]
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[[Category: Phosphatase]]
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[[Category: Protein binding]]
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[[Category: Rna repair]]
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Current revision

Structure of the Pnkp1/Rnl/Hen1 RNA repair complex

PDB ID 4xrp

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