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8c8g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of BoNT/Wo-NTNH complex== | |
| - | + | <StructureSection load='8c8g' size='340' side='right'caption='[[8c8g]], [[Resolution|resolution]] 2.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8c8g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Weissella_oryzae Weissella oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C8G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.98Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c8g OCA], [https://pdbe.org/8c8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c8g RCSB], [https://www.ebi.ac.uk/pdbsum/8c8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c8g ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BXWO_WEIOS BXWO_WEIOS] When overexpressed the N-terminus (residues 1-476) cleaves rat synaptobrevin-2/VAMP2 between '89-Trp-|-Trp-90' in vitro. This releases the cytoplasmic domain of VAMP2 from the synaptic vesicle membrane, which would prevent the assembly of the trans-SNARE complex on the membrane and thus prevent vesicle-target membrane fusion and neurotransmitter release (PubMed:27443638).<ref>PMID:27443638</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Weissella oryzae]] | ||
| + | [[Category: Kosenina S]] | ||
| + | [[Category: Skerlova J]] | ||
| + | [[Category: Stenmark P]] | ||
Current revision
Cryo-EM structure of BoNT/Wo-NTNH complex
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