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3pfy

From Proteopedia

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{{STRUCTURE_3pfy| PDB=3pfy | SCENE= }}
 
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===The catalytic domain of human OTUD5===
 
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==Function==
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==The catalytic domain of human OTUD5==
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[[http://www.uniprot.org/uniprot/OTUD5_HUMAN OTUD5_HUMAN]] Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro).<ref>PMID:17991829</ref> <ref>PMID:22245969</ref>
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<StructureSection load='3pfy' size='340' side='right'caption='[[3pfy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3pfy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PFY FirstGlance]. <br>
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[[3pfy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PFY OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.702&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pfy OCA], [https://pdbe.org/3pfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pfy RCSB], [https://www.ebi.ac.uk/pdbsum/3pfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pfy ProSAT]</span></td></tr>
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<references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OTUD5_HUMAN OTUD5_HUMAN] Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro).<ref>PMID:17991829</ref> <ref>PMID:22245969</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ubiquitinyl hydrolase 1]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Asinas, A E.]]
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[[Category: Asinas AE]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Crombet, L.]]
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[[Category: Crombet L]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Dong, A.]]
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[[Category: Dong A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Walker JR]]
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[[Category: Walker, J R.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Hydrolase]]
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[[Category: Peptidase c65 otubain]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

The catalytic domain of human OTUD5

PDB ID 3pfy

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