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3pml
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3pml is ON HOLD Authors: Bebenek, K., Pedersen, L.C., Kunkel, T.A. Description: crystal structure of a polymerase lambda variant with a dGTP analog...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==crystal structure of a polymerase lambda variant with a dGTP analog opposite a templating T== | |
| + | <StructureSection load='3pml' size='340' side='right'caption='[[3pml]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3pml]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PML FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1GC:2-DEOXY-5-O-[(R)-HYDROXY{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]METHYL}PHOSPHORYL]GUANOSINE'>1GC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pml OCA], [https://pdbe.org/3pml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pml RCSB], [https://www.ebi.ac.uk/pdbsum/3pml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pml ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bebenek K]] | ||
| + | [[Category: Kunkel TA]] | ||
| + | [[Category: Pedersen LC]] | ||
Current revision
crystal structure of a polymerase lambda variant with a dGTP analog opposite a templating T
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