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3pub

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==Crystal structure of the Bombyx mori low molecular weight lipoprotein 7 (Bmlp7)==
==Crystal structure of the Bombyx mori low molecular weight lipoprotein 7 (Bmlp7)==
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<StructureSection load='3pub' size='340' side='right' caption='[[3pub]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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<StructureSection load='3pub' size='340' side='right'caption='[[3pub]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pub]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bommo Bommo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PUB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pub]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PUB FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pub OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pub RCSB], [http://www.ebi.ac.uk/pdbsum/3pub PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pub OCA], [https://pdbe.org/3pub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pub RCSB], [https://www.ebi.ac.uk/pdbsum/3pub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pub ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
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</table>
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== Publication Abstract from PubMed ==
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== Function ==
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The hemolymph of the fifth instar larvae of the silkworm Bombyx mori contains a group of homologous proteins with a molecular weight of approximately 30kDa, termed B. mori low molecular weight lipoproteins (Bmlps), which account for about 5% of the total plasma proteins. These so-called "30K proteins" have been reported to be involved in the innate immune response and transportation of lipid and/or sugar. To elucidate their molecular functions, we determined the crystal structure of a 30K protein, Bmlp7, at 1.91A. It has two distinct domains: an all-alpha N-terminal domain (NTD) and an all-beta C-terminal domain (CTD) of the beta-trefoil fold. Comparative structural analysis indicates that Bmlp7 represents a new family, adding to the 14 families currently identified, of the beta-trefoil superfamily. Structural comparison and simulation suggest that the NTD has a putative lipid-binding cavity, whereas the CTD has a potential sugar-binding site. However, we were unable to detect the binding of either lipid or sugar. Therefore, further investigations are needed to characterize the molecular function of this protein.
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[https://www.uniprot.org/uniprot/E5EVW2_BOMMO E5EVW2_BOMMO]
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Crystal structure of the 30K protein from the silkworm Bombyx mori reveals a new member of the beta-trefoil superfamily.,Yang JP, Ma XX, He YX, Li WF, Kang Y, Bao R, Chen Y, Zhou CZ J Struct Biol. 2011 Jul;175(1):97-103. Epub 2011 Apr 14. PMID:21514389<ref>PMID:21514389</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bommo]]
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[[Category: Bombyx mori]]
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[[Category: Bao, R.]]
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[[Category: Large Structures]]
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[[Category: Chen, Y.]]
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[[Category: Bao R]]
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[[Category: He, Y X.]]
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[[Category: Chen Y]]
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[[Category: Kang, Y.]]
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[[Category: He Y-X]]
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[[Category: Li, W F.]]
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[[Category: Kang Y]]
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[[Category: Ma, X X.]]
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[[Category: Li W-F]]
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[[Category: Yang, J P.]]
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[[Category: Ma X-X]]
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[[Category: Zhou, C Z.]]
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[[Category: Yang J-P]]
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[[Category: Beta-trefoil fold]]
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[[Category: Zhou C-Z]]
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[[Category: Haemolymph]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of the Bombyx mori low molecular weight lipoprotein 7 (Bmlp7)

PDB ID 3pub

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