Tyrosine kinase 3D structures
From Proteopedia
(Difference between revisions)
(25 intermediate revisions not shown.) | |||
Line 8: | Line 8: | ||
*'''Fyn tyrosine kinase''' (Domains: SH3 80-141; SH2 142-247; kinase 260-537) | *'''Fyn tyrosine kinase''' (Domains: SH3 80-141; SH2 142-247; kinase 260-537) | ||
- | **[[1shf]], [[3ua6]] – hTK Fyn SH3 domain – human<br /> | + | **[[1shf]], [[3ua6]], [[7a2j]], [[7a2k]] – hTK Fyn SH3 domain – human<br /> |
- | **[[3h0f]], [[3h0h]], [[3h0i]], [[3cqt]], [[6ipz]], [[6ipy]] - hTK Fyn SH3 domain (mutant)<br /> | + | **[[3h0f]], [[3h0h]], [[3h0i]], [[3cqt]], [[6ipz]], [[6ipy]], [[7a2l]], [[7a2m]], [[7a2n]], [[7a2o]], [[7a2p]], [[7a2q]], [[7a2r]],[[7a2s]], [[7a2t]], [[7a2u]], [[7a2v]] - hTK Fyn SH3 domain (mutant)<br /> |
**[[1zbj]] - hTK Fyn SH3 domain – NMR<br /> | **[[1zbj]] - hTK Fyn SH3 domain – NMR<br /> | ||
**[[1g83]] - hTK Fyn SH2+SH3 domains (mutant)<br /> | **[[1g83]] - hTK Fyn SH2+SH3 domains (mutant)<br /> | ||
Line 15: | Line 15: | ||
**[[3uf4]] – mTK Fyn SH3-SH2 domain – mouse<br /> | **[[3uf4]] – mTK Fyn SH3-SH2 domain – mouse<br /> | ||
**[[3uf4]] - mTK Fyn SH2+SH3 domains<br /> | **[[3uf4]] - mTK Fyn SH2+SH3 domains<br /> | ||
- | **[[2l2p]], [[2lp5]] - cTK Fyn SH3 domain (mutant) - chicken - NMR<br /> | + | **[[2l2p]], [[2lp5]] - cTK Fyn SH3 domain (mutant)- chicken - NMR<br /> |
*Fyn complex | *Fyn complex | ||
**[[1fyn]], [[4znx]] - hTK Fyn SH3 domain + peptide<br /> | **[[1fyn]], [[4znx]] - hTK Fyn SH3 domain + peptide<br /> | ||
- | **[[ | + | **[[1a0n]], [[1azg]], [[1nyf]], [[1nyg]] - hTK Fyn SH3 domain + peptide – NMR<br /> |
- | **[[ | + | **[[1avz]], [[1efn]] - hTK Fyn SH3 domain + HIV Nef protein<br /> |
- | **[[4d8d]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br /> | + | **[[4d8d]], [[7d7s]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br /> |
**[[1m27]] - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide<br /> | **[[1m27]] - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide<br /> | ||
**[[4d8d]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br /> | **[[4d8d]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br /> | ||
**[[3ua7]] – hTK Fyn SH3 domain + hepatitis virus peptide<br /> | **[[3ua7]] – hTK Fyn SH3 domain + hepatitis virus peptide<br /> | ||
**[[4eik]] - hTK Fyn SH3 domain + VSL12 peptide<br /> | **[[4eik]] - hTK Fyn SH3 domain + VSL12 peptide<br /> | ||
+ | **[[7a2w]], [[7a2x]], [[7a2y]], [[7a2z]] - hTK Fyn SH3 domain (mutant) + VSL12 peptide<br /> | ||
**[[1aot]], [[1aou]] - hTK Fyn SH2 domain + phosphopeptide - NMR<BR /> | **[[1aot]], [[1aou]] - hTK Fyn SH2 domain + phosphopeptide - NMR<BR /> | ||
**[[2dq7]] – hTK kinase domain + staurosporine<br /> | **[[2dq7]] – hTK kinase domain + staurosporine<br /> | ||
Line 40: | Line 41: | ||
**[[5oaz]] - hTK SH3 domain <br /> | **[[5oaz]] - hTK SH3 domain <br /> | ||
+ | **[[7pw2]] - hTK SH3 domain (mutant) <br /> | ||
**[[1ju5]] - hTK SH3 domain (mutant) + CRK SH2 domain + phosphopeptide - NMR<br /> | **[[1ju5]] - hTK SH3 domain (mutant) + CRK SH2 domain + phosphopeptide - NMR<br /> | ||
**[[1awo]] - hTK SH3 domain + phosphopeptide – NMR<BR /> | **[[1awo]] - hTK SH3 domain + phosphopeptide – NMR<BR /> | ||
Line 45: | Line 47: | ||
**[[2o88]] - hTK SH3 domain (mutant} + peptide<br /> | **[[2o88]] - hTK SH3 domain (mutant} + peptide<br /> | ||
**[[4jjb]], [[4jjc]], [[4jjd]] - hTK abl SH3 domain <br /> | **[[4jjb]], [[4jjc]], [[4jjd]] - hTK abl SH3 domain <br /> | ||
- | **[[ | + | **[[3eg0]], [[3eg1]], [[3eg2]], [[3eg3]], [[3egu]], [[4j9b]] - hTK abl SH3 domain (mutant)<br /> |
**[[4j9c]], [[4j9e]], [[4j9i]] - hTK abl SH3 domain (mutant) + p17 peptide<br /> | **[[4j9c]], [[4j9e]], [[4j9i]] - hTK abl SH3 domain (mutant) + p17 peptide<br /> | ||
**[[4j9d]], [[4j9f]] - hTK abl SH3 domain (mutant) + p0 peptide<br /> | **[[4j9d]], [[4j9f]] - hTK abl SH3 domain (mutant) + p0 peptide<br /> | ||
Line 65: | Line 67: | ||
**[[6bl8]] - hTK kinase domain<br /> | **[[6bl8]] - hTK kinase domain<br /> | ||
**[[2g2h]] - hTK kinase domain (mutant)<br /> | **[[2g2h]] - hTK kinase domain (mutant)<br /> | ||
+ | **[[6xr6]], [[6xr7]], [[6xrg]] - hTK kinase domain (mutant) - NMR<br /> | ||
**[[2g1t]] - hTK kinase domain + peptide<br /> | **[[2g1t]] - hTK kinase domain + peptide<br /> | ||
- | **[[ | + | **[[2g2f]], [[2g2i]] - hTK kinase domain (mutant) + peptide<br /> |
- | **[[ | + | **[[2gqg]], [[2hzi]], [[2hz4]], [[2hz0]], [[2hyy]], [[3cs9]], [[3ue4]], [[4wa9]], [[7n9g]] - hTK kinase domain + cancer drug<br /> |
**[[2f4j]], [[4twp]] - hTK kinase domain (mutant) + cancer drug<br /> | **[[2f4j]], [[4twp]] - hTK kinase domain (mutant) + cancer drug<br /> | ||
- | **[[ | + | **[[2e2b]], [[2hiw]], [[2v7a]], [[3qrk]], [[3qri]], [[3qrj]], [[4zog]], [[5hu9]], [[4yc8]], [[3pyy]], [[6npv]], [[6npu]], [[6npe]], [[7cc2]], [[7dt2]], [[7w7x]], [[7w7y]] - hTK kinase domain + inhibitor<br /> |
**[[1opj]], [[1opk]] - mTK kinase domain <br /> | **[[1opj]], [[1opk]] - mTK kinase domain <br /> | ||
**[[1fpu]], [[1m52]], [[2qoh]], [[3kf4]], [[3kfa]] - mTK kinase domain + inhibitor<br /> | **[[1fpu]], [[1m52]], [[2qoh]], [[3kf4]], [[3kfa]] - mTK kinase domain + inhibitor<br /> | ||
Line 103: | Line 106: | ||
**[[2kk1]] – hTK C terminal – NMR<BR /> | **[[2kk1]] – hTK C terminal – NMR<BR /> | ||
- | |||
- | *'''Anaplastic lymphoma kinase (Alk)''' or '''Alk tyrosine kinae receptor''' | ||
- | |||
- | **[[4tt7]], [[6cdt]] - hTK kinase domain<br /> | ||
- | **[[3l9p]], [[3lcs]], [[3lct]], [[2yhv]], [[2yjr]], [[2yjs]], [[4fnw]], [[4fnx]], [[4anl]] - hTK kinase domain (mutant)<br /> | ||
- | **[[2xb7]], [[2xba]], [[3aox]], [[5imx]], [[5kz0]], [[4ccb]], [[4ccu]], [[4cli]], [[4cmo]], [[4cmt]], [[4cmu]], [[4cnh]], [[4ctb]], [[4ctc]], [[6mx8]], [[6edl]], [[6ebw]], [[6e0r]] - hTK kinase domain + inhibitor<br /> | ||
- | **[[4dce]], [[4fob]], [[4foc]], [[4fod]], [[4fny]], [[4fnz]], [[4joa]], [[4mkc]], [[4z55]], [[5iug]], [[5iuh]], [[5iui]], [[4cd0]], [[4clj]] - hTK kinase domain (mutant) + inhibitor<br /> | ||
- | **[[2xp2]], [[6mx8]], [[5fto]], [[5ftq]] - hTK kinase domain + cancer drug<br /> | ||
- | **[[2yfx]], [[4anq]], [[4ans]], [[5aaa]], [[5aab]], [[5aac]], [[5a9u]], [[5aa8]], [[5aa9]] - hTK kinase domain (mutant) + cancer drug<br /> | ||
*'''Csk tyrosine kinase''' | *'''Csk tyrosine kinase''' | ||
Line 123: | Line 117: | ||
**[[3d7t]], [[3d7u]] - hTK kinase domain (mutant) + C-Src<br /> | **[[3d7t]], [[3d7u]] - hTK kinase domain (mutant) + C-Src<br /> | ||
**[[1k9a]] - TK C terminal - rat<br /> | **[[1k9a]] - TK C terminal - rat<br /> | ||
+ | |||
+ | *'''Fgr tyrosine kinase''' | ||
+ | |||
+ | **[[7uy0]] - hTK 80-527 + inhibitor<br /> | ||
+ | **[[7uy3]] - hTK 80-527 (mutant) + inhibitor<br /> | ||
+ | **[[7jt9]] - hTK SH3 domain 77-138<br /> | ||
*'''Jak tyrosine kinase''' see [[Janus kinase]] | *'''Jak tyrosine kinase''' see [[Janus kinase]] | ||
Line 144: | Line 144: | ||
**[[1f2f]] - cTK (mutant) <br /> | **[[1f2f]] - cTK (mutant) <br /> | ||
**[[1shd]] - cTK + TRKA receptor<br /> | **[[1shd]] - cTK + TRKA receptor<br /> | ||
- | **[[1f1w]] - cTK (mutant) + peptide<br /> | ||
**[[1p13]] - cTK + peptide<br /> | **[[1p13]] - cTK + peptide<br /> | ||
+ | **[[1f1w]] - cTK (mutant) + peptide<br /> | ||
**[[1spr]] - RsvTK + phosphate – Rous sarcoma virus<br /> | **[[1spr]] - RsvTK + phosphate – Rous sarcoma virus<br /> | ||
**[[2jyq]] – RsvTK – NMR<br /> | **[[2jyq]] – RsvTK – NMR<br /> | ||
- | **[[1kc2]], [[ | + | **[[1kc2]], [[1is0]], [[1nzl]], [[1nzv]], [[1sps]] - RsvTK + peptide<br /> |
**[[1sha]], [[1shb]] - RsvTK + phosphopeptide<br /> | **[[1sha]], [[1shb]] - RsvTK + phosphopeptide<br /> | ||
**[[1qwe]], [[1qwf]] - RsvTK + peptide<br /> | **[[1qwe]], [[1qwf]] - RsvTK + peptide<br /> | ||
Line 155: | Line 155: | ||
**[[6c4s]] – hTK + choline kinase peptide<br /> | **[[6c4s]] – hTK + choline kinase peptide<br /> | ||
- | **[[1jeg]] – mTK + protein-tyrosine phosphatase peptide <br /> | + | **[[1jeg]] – mTK + protein-tyrosine phosphatase peptide<br /> |
**[[1srl]], [[1srm]] - cTK – NMR<br /> | **[[1srl]], [[1srm]] - cTK – NMR<br /> | ||
**[[3fj5]], [[4jz3]], [[4jz4]], [[6xvo]], [[6xvn]] - cTK<br /> | **[[3fj5]], [[4jz3]], [[4jz4]], [[6xvo]], [[6xvn]] - cTK<br /> | ||
- | **[[4le9]], [[4oml]], [[4omm]], [[4omn]], [[4omo]], [[4omp]], [[4omq]], [[5i11]], [[ | + | **[[4le9]], [[4oml]], [[4omm]], [[4omn]], [[4omo]], [[4omp]], [[4omq]], [[4rtu]], [[4rtx]], [[5i11]], [[7a30]], [[7a31]], [[7a32]], [[7a33]], [[7a34]], [[7a35]], [[7a36]], [[7a37]], [[7a38]], [[7a39]], [[7a3a]], [[7a3b]], [[7a3c]], [[7a3d]], [[7a3e]], [[7ner]], [[7nes]], [[7net]] - cTK (mutant) <br /> |
**[[6xx3]], [[6xx2]], [[6xx5]], [[6xx4]], [[6xx5]], [[6xx2]] - cTK (mutant) + ion<br /> | **[[6xx3]], [[6xx2]], [[6xx5]], [[6xx4]], [[6xx5]], [[6xx2]] - cTK (mutant) + ion<br /> | ||
- | **[[ | + | **[[2pri]], [[4hxj]], [[4qt7]], [[4rty]], [[4rtz]] - cTK + peptide<br /> |
**[[1prm]], [[1rlp]], [[1rlq]], [[1nlo]], [[1nlp]] - cTK + peptide - NMR<br /> | **[[1prm]], [[1rlp]], [[1rlq]], [[1nlo]], [[1nlp]] - cTK + peptide - NMR<br /> | ||
**[[4hvu]], [[4hvv]], [[4hvw]], [[4rtv]], [[4rtw]], [[5ob2]], [[5ob1]], [[5ob0]], [[5oav]] - cTK (mutant) + peptide<br /> | **[[4hvu]], [[4hvv]], [[4hvw]], [[4rtv]], [[4rtw]], [[5ob2]], [[5ob1]], [[5ob0]], [[5oav]] - cTK (mutant) + peptide<br /> | ||
Line 169: | Line 169: | ||
**[[1yo6]] - hTK <br /> | **[[1yo6]] - hTK <br /> | ||
**[[1yoj]] - hTK (mutant) <br /> | **[[1yoj]] - hTK (mutant) <br /> | ||
- | **[[2bdf]], [[2bdj]], [[6e6e]], [[6ate]] – hTK + inhibitor<br /> | + | **[[2bdf]], [[2bdj]], [[6e6e]], [[6ate]], [[7ng7]] – hTK + inhibitor<br /> |
**[[1yol]], [[1yom]] – hTK (mutant) + inhibitor<br /> | **[[1yol]], [[1yom]] – hTK (mutant) + inhibitor<br /> | ||
**[[1byg]] – hTK + staurosporine<br /> | **[[1byg]] – hTK + staurosporine<br /> | ||
Line 175: | Line 175: | ||
**[[4mxx]], [[4mxy]], [[4mxz]] – hTK (mutant) + cancer drug<br /> | **[[4mxx]], [[4mxy]], [[4mxz]] – hTK (mutant) + cancer drug<br /> | ||
**[[3of0]], [[2qi8]] - cTK (mutant) <br /> | **[[3of0]], [[2qi8]] - cTK (mutant) <br /> | ||
+ | **[[3d7t]], [[3d7u]] – cTK + Csk<br /> | ||
+ | **[[3dqw]], [[3dqx]] - cTK (mutant) + ATP<br /> | ||
**[[3tz7]], [[3tz8]], [[3tz9]], [[4dgg]] – cTK (mutant) + pyrazolin derivative<br /> | **[[3tz7]], [[3tz8]], [[3tz9]], [[4dgg]] – cTK (mutant) + pyrazolin derivative<br /> | ||
- | **[[4fic]], [[3uqg]], [[3uqf]], [[3u51]], [[3u4w]], [[4agw]], [[3qlg]], [[3qlf]], [[3g6g]], [[3el8]], [[3f6x]], [[2hwo]], [[2hwp]], [[2oiq]], [[3en4]], [[3en5]], [[3en6]], [[3en7]], [[3el7]], [[5bmm]], [[5j5s]], [[4ybj]], [[4ybk]], [[5xp7]], [[ | + | **[[4fic]], [[3uqg]], [[3uqf]], [[3u51]], [[3u4w]], [[4agw]], [[3qlg]], [[3qlf]], [[3g6g]], [[3el8]], [[3f6x]], [[2hwo]], [[2hwp]], [[2oiq]], [[3en4]], [[3en5]], [[3en6]], [[3en7]], [[3el7]], [[5bmm]], [[5j5s]], [[4ybj]], [[4ybk]], [[5xp7]], [[7ah3]], [[7d57]], [[7d5o]] – cTK + inhibitor<br /> |
+ | **[[7wf5]] – cTK + cancer drug<br /> | ||
**[[4lgg]], [[4lgh]], [[3svv]], [[3oez]], [[3lok]], [[3g5d]], [[3f3w]], [[3f3v]], [[3geq]], [[3g6h]], [[3f3t]], [[3f3u]], [[2qlq]], [[2qq7]], [[4lgg]], [[4lgh]], [[4mcv]], [[4o2p]], [[5teh]], [[5t0p]], [[5sys]], [[5swh]], [[6hve]], [[6hvf]] – cTK (mutant) + inhibitor<br /> | **[[4lgg]], [[4lgh]], [[3svv]], [[3oez]], [[3lok]], [[3g5d]], [[3f3w]], [[3f3v]], [[3geq]], [[3g6h]], [[3f3t]], [[3f3u]], [[2qlq]], [[2qq7]], [[4lgg]], [[4lgh]], [[4mcv]], [[4o2p]], [[5teh]], [[5t0p]], [[5sys]], [[5swh]], [[6hve]], [[6hvf]] – cTK (mutant) + inhibitor<br /> | ||
- | **[[6l8l]] – cTK + cancer drug<br /> | ||
**[[4u5j]] – cTK (mutant) + cancer drug<br /> | **[[4u5j]] – cTK (mutant) + cancer drug<br /> | ||
- | **[[3d7t]], [[3d7u]] – cTK + Csk<br /> | ||
- | **[[3dqw]], [[3dqx]] - cTK (mutant) + ATP<br /> | ||
*Src tyrosine kinase C terminal domain | *Src tyrosine kinase C terminal domain | ||
Line 222: | Line 222: | ||
**[[1x27]] - hTK Lck SH3-SH2 domain + peptide<br /> | **[[1x27]] - hTK Lck SH3-SH2 domain + peptide<br /> | ||
**[[1qpj]] - hTK Lck kinase domain + staurosporin<br /> | **[[1qpj]] - hTK Lck kinase domain + staurosporin<br /> | ||
- | **[[ | + | **[[1qpc]], [[1qpd]], [[1qpe]], [[2of2]], [[2of4]], [[2ofu]], [[2ofv]], [[2og8]], [[2zm1]], [[2zm4]], [[2zyb]], [[3ac1]], [[3ac2]], [[3ac3]], [[3ac4]], [[3ac5]], [[3ac8]], [[3acj]], [[3ack]], [[3ad4]], [[3ad5]], [[3ad6]], [[3b2w]], [[3bym]], [[3bys]], [[3byu]], [[3byo]], [[3kmm]], [[6pdj]] - hTK Lck kinase domain + inhibitor<br /> |
**[[3mpm]] - hTK Lck kinase domain (mutant) + inhibitor<br /> | **[[3mpm]] - hTK Lck kinase domain (mutant) + inhibitor<br /> | ||
**[[4c3f]] - hTK Lck kinase domain (mutant) + chemotype<br /> | **[[4c3f]] - hTK Lck kinase domain (mutant) + chemotype<br /> | ||
Line 232: | Line 232: | ||
*'''Syk - spleen tyrosine kinase''' | *'''Syk - spleen tyrosine kinase''' | ||
- | **[[1xba]], [[4xg2]] – hSyk kinase domain | + | **[[1xba]], [[4xg2]] – hSyk kinase domain residues 337-635 |
*Syk complex | *Syk complex | ||
Line 238: | Line 238: | ||
**[[1xbb]] - hSyk kinase domain + Gleevec<br /> | **[[1xbb]] - hSyk kinase domain + Gleevec<br /> | ||
**[[1xbc]] - hSyk kinase domain + staurosporine<br /> | **[[1xbc]] - hSyk kinase domain + staurosporine<br /> | ||
- | **[[3emg]], [[3fqe]], [[3fqh]], [[3fqs]], [[3srv]], [[ | + | **[[3emg]], [[3fqe]], [[3fqh]], [[3fqs]], [[3srv]], [[3tub]], [[3tuc]], [[3tud]], [[3vf8]], [[3vf9]], [[4dfl]], [[4dfn]], [[4f4p]], [[4fyn]], [[4fyo]], [[4fz6]], [[4fz7]], [[4gfg]], [[4i0r]], [[4i0s]], [[4i0t]], [[4puz]], [[4pv0]], [[4rx7]], [[4rx8]], [[4rx9]], [[4wnm]], [[4xg3]], [[4xg4]], [[4xg6]], [[4xg7]], [[4xg8]], [[4xg9]], [[4rss]], [[4yjo]], [[4yjp]], [[4yjq]], [[4yjr]], [[4yjs]], [[4yjt]], [[4yju]], [[4yjv]], [[5c26]], [[5c27]], [[5ghv]], [[5lma]], [[5lmb]], [[5tr6]], [[5tt7]], [[5tiu]], [[5t68]], [[5y5t]], [[5y5u]], [[6hm6]], [[6hm7]], [[6vov]], [[6zc0]], [[6zcp]], [[6zcq]], [[6zcr]], [[6zcs]], [[6zcu]], [[6zcx]], [[6zcy]], [[8bi2]] - hSyk kinase domain + inhibitor<br /> |
**[[4px6]], [[5cxh]], [[5cxz]], [[5cy3]] - hSyk kinase domain (mutant) + inhibitor<br /> | **[[4px6]], [[5cxh]], [[5cxz]], [[5cy3]] - hSyk kinase domain (mutant) + inhibitor<br /> | ||
**[[1csy]], [[1csz]] - hSyk SH2 domain + phosphopeptide – NMR<BR /> | **[[1csy]], [[1csz]] - hSyk SH2 domain + phosphopeptide – NMR<BR /> | ||
**[[4fl1]], [[4fl2]] - hSyk kinase domain + ANP<br /> | **[[4fl1]], [[4fl2]] - hSyk kinase domain + ANP<br /> | ||
**[[4fl3]] - hSyk kinase domain (mutant) + ANP<br /> | **[[4fl3]] - hSyk kinase domain (mutant) + ANP<br /> | ||
- | **[[1a81]] – hSyk tandem SH2 domain + T-cell surface peptide <br /> | + | **[[7q63]], [[7sa7]] – hSyk tandem SH2 domain <br /> |
+ | **[[1a81]], [[7q5t]], [[7q5u]], [[7q5w]] – hSyk tandem SH2 domain + T-cell surface peptide <br /> | ||
*'''Itk/Tsk tyrosine kinase''' or interleukin-2 tyrosine kinase; domains – SH2 236-344; SH3 160-236; kinase 357-620 | *'''Itk/Tsk tyrosine kinase''' or interleukin-2 tyrosine kinase; domains – SH2 236-344; SH3 160-236; kinase 357-620 | ||
Line 285: | Line 286: | ||
**[[3fzp]] - hTK Pyk2 kinase domain + ATPγS<br /> | **[[3fzp]] - hTK Pyk2 kinase domain + ATPγS<br /> | ||
- | **[[ | + | **[[3et7]], [[3fzr]], [[3fzs]], [[3fzt]], [[3h3c]], [[4h1j]], [[4h1m]], [[5to8]], [[5tob]] - hTK Pyk2 kinase domain + inhibitor<br /> |
**[[3gm1]], [[4r32]] - hTK Pyk2 FAT domain + paxillin peptide<br /> | **[[3gm1]], [[4r32]] - hTK Pyk2 FAT domain + paxillin peptide<br /> | ||
- | **[[ | + | **[[4xef]], [[4xek]], [[4xev]] - hTK Pyk2 FAT domain + leupaxin peptide<br /> |
**[[4h1j]] - hFAK2 kinase domain + pyrazole inhibitor<br /> | **[[4h1j]] - hFAK2 kinase domain + pyrazole inhibitor<br /> | ||
**[[3h3c]] - hFAK2 kinase domain + pyrimidine inhibitor<br /> | **[[3h3c]] - hFAK2 kinase domain + pyrimidine inhibitor<br /> | ||
Line 310: | Line 311: | ||
**[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br /> | **[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br /> | ||
**[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br /> | **[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br /> | ||
+ | |||
+ | *'''Ptk7 tyrosine kinase or inactive tyrosine-protein kinase 7''' | ||
+ | |||
+ | **[[6vg3]] - hTK Ptk7 kinase domain <br /> | ||
*'''PtkA tyrosine kinase''' | *'''PtkA tyrosine kinase''' | ||
Line 358: | Line 363: | ||
**[[3la6]] - EcTK Wzc kinase domain <br /> | **[[3la6]] - EcTK Wzc kinase domain <br /> | ||
+ | **[[7ni2]], [[7nib]] - EcTK Wzc – Cryo EM <br /> | ||
+ | **[[7dhd]] - VvTK Wzc – Vibrio vulnificus <br /> | ||
+ | **[[7dhe]], [[7dhf]] - VvTK Wzc + inhibitor <br /> | ||
*'''Ros tyrosine kinase''' | *'''Ros tyrosine kinase''' | ||
Line 364: | Line 372: | ||
**[[4uxl]] - hTK Ros kinase domain + inhibitor<br /> | **[[4uxl]] - hTK Ros kinase domain + inhibitor<br /> | ||
- | *'''Tyk2 tyrosine kinase''' (Domains: SH2+FERM 23-540; pseudokinase 541-880; kinase 880-1170) | + | *'''Non-receptor Tyk2 tyrosine kinase''' (Domains: SH2+FERM 23-540; pseudokinase 541-880; kinase 880-1170) |
**[[5f20]], [[5f1z]], [[6ova]] - hTK Tyk2 kinase domain + inhibitor<br /> | **[[5f20]], [[5f1z]], [[6ova]] - hTK Tyk2 kinase domain + inhibitor<br /> | ||
Line 372: | Line 380: | ||
**[[4oli]] - hTK Tyk2 pseudokinase + kinase domains <br /> | **[[4oli]] - hTK Tyk2 pseudokinase + kinase domains <br /> | ||
**[[3zon]], [[5c01]], [[5c03]] - hTK Tyk2 pseudokinase domain <br /> | **[[3zon]], [[5c01]], [[5c03]] - hTK Tyk2 pseudokinase domain <br /> | ||
- | **[[4wov]], [[5tkd]], [[6nzr]], [[6nzq]], [[6nzp]], [[6nzh]], [[6nzf]], [[6nze]], [[6nsl]] - hTK Tyk2 pseudokinase domain + inhibitor<br /> | + | **[[4wov]], [[5tkd]], [[6nzr]], [[6nzq]], [[6nzp]], [[6nzh]], [[6nzf]], [[6nze]], [[6nsl]], [[7ax4]], [[7k7o]], [[7k7q]] - hTK Tyk2 pseudokinase domain + inhibitor<br /> |
**[[4po6]] - hTK Tyk2 SH2+FERM domains + IFNAR1 peptide<br /> | **[[4po6]] - hTK Tyk2 SH2+FERM domains + IFNAR1 peptide<br /> | ||
*'''Hck tyrosine kinase''' Domains: SH3 81-137; SH2 119-224; SH1 or kinase+C-terminal 225-525; | *'''Hck tyrosine kinase''' Domains: SH3 81-137; SH2 119-224; SH1 or kinase+C-terminal 225-525; | ||
- | **[[3hck]] - hTK | + | **[[3hck]] - hTK SH2 domain - NMR<BR /> |
- | **[[1bu1]] - hTK | + | **[[1bu1]] - hTK SH3 domain <BR /> |
- | **[[4hck]], [[5hck]] - hTK | + | **[[4hck]], [[5hck]] - hTK SH3 domain - NMR<BR /> |
- | **[[2oj2]], [[2oi3]] - hTK | + | **[[2oj2]], [[2oi3]] - hTK SH3 domain + peptide - NMR<BR /> |
- | **[[3rbb]], [[3rea]], [[3reb]] - hTK | + | **[[3rbb]], [[3rea]], [[3reb]] - hTK SH3 domain (mutant) + HIV NEF<BR /> |
- | **[[5nuh]] - hTK | + | **[[5nuh]] - hTK SH3 domain + SIV NEF<BR /> |
- | **[[4orz]] - hTK | + | **[[4orz]] - hTK SH3 domain (mutant) + HIV NEF + single domain antibody<br /> |
- | **[[3nhn]] - hTK | + | **[[3nhn]] - hTK SH3-SH2-linker domain <BR /> |
**[[4u5w]] - hTK Hck SH3-SH2 domains + NEF <br /> | **[[4u5w]] - hTK Hck SH3-SH2 domains + NEF <br /> | ||
- | **[[2c0i]], [[2c0o]], [[2c0t]] - hTK | + | **[[2c0i]], [[2c0o]], [[2c0t]] - hTK SH3-SH2-SH1 domain + inhibitor<BR /> |
- | **[[5h0b]], [[5h0e]], [[5h0g]], [[5h0h]] - hTK | + | **[[5h0b]], [[5h0e]], [[5h0g]], [[5h0h]] - hTK SH3-SH2-SH1 domain (mutant) + inhibitor<BR /> |
- | **[[2hk5]], [[5zj6]] - hTK | + | **[[2hk5]], [[5zj6]] - hTK kinase domain + inhibitor<BR /> |
- | **[[1qcf]], [[3vrz]], [[3vs0]], [[3vs3]], [[3vs4]], [[3vs5]], [[3vs6]], [[3vs7]] - hTK | + | **[[1qcf]], [[3vrz]], [[3vs0]], [[3vs3]], [[3vs4]], [[3vs5]], [[3vs6]], [[3vs7]] - hTK SH3-SH2-kinase-C-terminal domain + inhibitor<BR /> |
- | **[[3vry]], [[3vs1]], [[3vs2]] - hTK | + | **[[3vry]], [[3vs1]], [[3vs2]] - hTK SH3-SH2-kinase-C-terminal domain (mutant) + inhibitor<BR /> |
- | **[[1ad5]] - hTK | + | **[[1ad5]] - hTK SH3-SH2-kinase-C-terminal domain + AMPPNP<BR /> |
- | **[[2hck]] - hTK | + | **[[2hck]] - hTK SH3-SH2-kinase-C-terminal domain + quercetin<BR /> |
- | **[[4lud]], [[4lue]] - hTK | + | **[[4lud]], [[4lue]] - hTK SH2+SH3+kinase+C-terrminal domain (mutant) + fluorescent compound<br /> |
*'''Ack1 tyrosine kinase''' or activated cdc42 kinase 1 | *'''Ack1 tyrosine kinase''' or activated cdc42 kinase 1 | ||
- | **[[1u46]], [[4hzr]] - hTK Ack1 kinase domain <br /> | + | **[[1u46]], [[4hzr]] - hTK Ack1 kinase domain 115-389<br /> |
**[[4hzs]] - hTK Ack1 kinase+SH3 domains <br /> | **[[4hzs]] - hTK Ack1 kinase+SH3 domains <br /> | ||
- | **[[1u4d]], [[3eqp]], [[3eqr]], [[4ewh]], [[4id7]], [[5zxb]] - hTK Ack1 kinase domain + inhibitor<br /> | + | **[[1u4d]], [[3eqp]], [[3eqr]], [[4ewh]], [[4id7]], [[5zxb]], [[7kp6]], [[8hmt]] - hTK Ack1 kinase domain + inhibitor<br /> |
+ | **[[8fe9]] - hTK Ack1 kinase domain (mutant) + inhibitor<br /> | ||
+ | |||
*'''RECEPTOR TYROSINE KINASES - RTK''' | *'''RECEPTOR TYROSINE KINASES - RTK''' | ||
- | * | + | *Burton’s tyrosine kinase (Domains: PH 1-170; SH3 216-273; SH2 273-378; kinase 378-659) |
+ | **[[8gmb]] - hTK Btk <br /> | ||
**[[2z0p]] - hTK Btk PH domain<br /> | **[[2z0p]] - hTK Btk PH domain<br /> | ||
- | **[[1btk | + | **[[1btk]] – hTK Btk PH domain (mutant) <br /> |
**[[3p08]], [[1k2p]] - hTK Btk kinase domain<br /> | **[[3p08]], [[1k2p]] - hTK Btk kinase domain<br /> | ||
**[[1aww]], [[1awx]], [[1qly]] - hTK Btk SH3 domain – NMR<BR /> | **[[1aww]], [[1awx]], [[1qly]] - hTK Btk SH3 domain – NMR<BR /> | ||
Line 412: | Line 423: | ||
**[[4xi2]] - hTK Btk SH3-SH2-kinase domain<br /> | **[[4xi2]] - hTK Btk SH3-SH2-kinase domain<br /> | ||
**[[4y95]] - bTK Btk kinase domain (mutant) - bovine<br /> | **[[4y95]] - bTK Btk kinase domain (mutant) - bovine<br /> | ||
- | **[[4y93]] - bTK Btk PH+kinase domains (mutant) <br /> | + | **[[4y93]], [[8s93]] - bTK Btk PH+kinase domains (mutant) <br /> |
*Btk complex | *Btk complex | ||
**[[1b55]] - hTK Btk PH domain + inositol-tetrakisphosphate<br /> | **[[1b55]] - hTK Btk PH domain + inositol-tetrakisphosphate<br /> | ||
- | **[[6tse]], [[6tvn]] - hTK Btk PH domain (mutant) + indoline derivative<br /> | ||
**[[1bwn]] - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate<br /> | **[[1bwn]] - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate<br /> | ||
- | **[[ | + | **[[6yyf]], [[6yyg]], [[6yyk]] - hTK Btk PH domain (mutant) + inhibitor<br /> |
- | **[[3gen]], [[3ocs]], [[3pix]], [[3piy]], [[3piz]], [[3pj1]], [[3pj2]], [[3pj3]], [[4nwm]], [[ | + | **[[3gen]], [[3ocs]], [[3pix]], [[3piy]], [[3piz]], [[3pj1]], [[3pj2]], [[3pj3]], [[4nwm]], [[4rx5]], [[4yhf]], [[4z3v]], [[4zly]], [[4zlz]], [[5bpy]], [[5bq0]], [[5fbn]], [[5fbo]], [[5j87]], [[5jrs]], [[5kup]], [[5p9f]], [[5p9g]], [[5p9h]], [[5p9i]], [[5p9j]], [[5p9k]], [[5p9l]], [[5p9m]], [[5t18]], [[5u9d]], [[5vfi]], [[5vgo]], [[5xyz]], [[5zz4]], [[6aua]], [[6aub]], [[6bik]], [[6bke]], [[6bkh]], [[6bkw]], [[6bln]], [[6di0]], [[6di1]], [[6di3]], [[6di5]], [[6di9]], [[6e4f]], [[6e9p]], [[6n9p]], [[6nzm]], [[6nfh]], [[6nfi]], [[6o8i]], [[6s90]], [[6tfp]], [[6vxq]], [[6w06]], [[6w07]], [[6x3n]], [[6x3o]], [[6x3p]], [[6xe4]], [[7kxl]], [[7kxm]], [[7kxn]], [[7kxo]], [[7kxp]], [[7kxq]], [[7lty]], [[7ltz]], [[7n4q]], [[7n4r]], [[7n4s]], [[7n5o]], [[7n5r]], [[7n5x]], [[7n5y]], [[7r60]], [[7r61]], [[7yc9]], [[8e2m]], [[8ejb]], [[8flg]], [[8flh]], [[8flv]], [[8gc7]] - hTK Btk kinase domain + inhibitor<br /> |
- | **[[3k54]], [[3t9t]], [[4ot5]], [[4ot6]], [[4otq]], [[4otr]], [[4otf]], [[4rfy]], [[4rfz]], [[4rg0]], [[6ep9]], [[6hrt]], [[6hrp]] - hTK Btk kinase domain (mutant) + inhibitor<br /> | + | **[[3k54]], [[3t9t]], [[4ot5]], [[4ot6]], [[4otq]], [[4otr]], [[4otf]], [[4rfy]], [[4rfz]], [[4rg0]], [[6ep9]], [[6hrt]], [[6hrp]], [[8ff0]], [[8gc8]] - hTK Btk kinase domain (mutant) + inhibitor<br /> |
- | **[[5vgo]], [[ | + | **[[6w7o]], [[6w8i]], [[8dso]] - hTK Btk kinase domain + cIAP + inhibitor<br /> |
- | **[[3oct]] - hTK Btk kinase domain (mutant) + cancer drug<br /> | + | **[[5vgo]], [[7l5o]], [[7l5p]], [[8fll]], [[8u2d]], [[8u2e]] - hTK Btk kinase domain + cancer drug<br /> |
+ | **[[3oct]], [[8fd9]], [[8fln]] - hTK Btk kinase domain (mutant) + cancer drug<br /> | ||
**[[6omu]] - hTK Btk kinase domain + MS drug<br /> | **[[6omu]] - hTK Btk kinase domain + MS drug<br /> | ||
**[[6j6m]] - hTK Btk kinase domain + MCL drug<br /> | **[[6j6m]] - hTK Btk kinase domain + MCL drug<br /> | ||
Line 430: | Line 441: | ||
*'''c-FMS tyrosine kinase or macrophage colony-stimulating factor 1 receptor''' see [[Colony-stimulating factor receptor]] | *'''c-FMS tyrosine kinase or macrophage colony-stimulating factor 1 receptor''' see [[Colony-stimulating factor receptor]] | ||
- | |||
- | *'''DDR1 and DDR2 tyrosine kinase receptors''' see [[Epithelial discoidin domain-containing receptor]] | ||
*'''Kit tyrosine kinase''' or mast/stem cell growth factor receptor Kit; Domains – extracellular 1-519; kinase 547-693, 754-935 | *'''Kit tyrosine kinase''' or mast/stem cell growth factor receptor Kit; Domains – extracellular 1-519; kinase 547-693, 754-935 | ||
Line 439: | Line 448: | ||
**[[2e9w]] - hTK Kit extracellular domain + stem cell factor<br /> | **[[2e9w]] - hTK Kit extracellular domain + stem cell factor<br /> | ||
**[[1t45]], [[4pgz]] - hTK Kit kinase domain<br /> | **[[1t45]], [[4pgz]] - hTK Kit kinase domain<br /> | ||
- | **[[1t46]], [[4u0i]], [[ | + | **[[1t46]], [[4u0i]], [[6kia]], [[6mob]] - hTK Kit kinase domain + cancer drug<br /> |
- | **[[6gqj]], [[ | + | **[[6gqj]], [[6gqk]], [[6gql]], [[6gqm]] - hTK Kit kinase domain (mutant) + cancer drug<br /> |
- | **[[6itv]], [[6itt]] - hTK Kit kinase domain + inhibitor<br /> | + | **[[6itv]], [[6itt]], [[6xv9]], [[6xva]], [[6xvb]], [[7khg]], [[7khj]], [[7khk]] - hTK Kit kinase domain + inhibitor<br /> |
**[[4hvs]], [[6hh1]] - hTK Kit kinase domain (mutant) + inhibitor<br /> | **[[4hvs]], [[6hh1]] - hTK Kit kinase domain (mutant) + inhibitor<br /> | ||
**[[2o26]] - hTK Kit residues 25-314 + Kit ligand<br /> | **[[2o26]] - hTK Kit residues 25-314 + Kit ligand<br /> | ||
Line 449: | Line 458: | ||
**[[2dbj]] - hTK Mer FN3 domain – NMR<BR /> | **[[2dbj]] - hTK Mer FN3 domain – NMR<BR /> | ||
- | **[[2p0c]] - hTK Mer kinase domain | + | **[[2p0c]] - hTK Mer kinase domain<br /> |
*Mer complex | *Mer complex | ||
Line 456: | Line 465: | ||
**[[3brb]] - hTK Mer kinase domain + ADP<br /> | **[[3brb]] - hTK Mer kinase domain + ADP<br /> | ||
**[[2p0c]] - hTK Mer kinase domain + ANP<br /> | **[[2p0c]] - hTK Mer kinase domain + ANP<br /> | ||
- | **[[3bpr]], [[3tcp]], [[4m3q]], [[4mh7]], [[4mha]], [[ | + | **[[3bpr]], [[3tcp]], [[4m3q]], [[4mh7]], [[4mha]], [[5k0k]], [[5k0x]], [[5tc0]], [[5td2]], [[5u6c]], [[6mep]], [[7avx]], [[7aw4]], [[7cqe]], [[7m5z]], [[7oam]], [[7ols]], [[7olv]], [[7olx]] - hTK Mer kinase domain + inhibitor<br /> |
- | **[[7ab2]], [[7aax]], [[7aaz]] - hTK Mer kinase domain (mutant) + inhibitor<br /> | + | **[[7ab2]], [[7aax]], [[7aaz]], [[7avy]], [[7avz]], [[7aw0]], [[7aw1]], [[7aw2]], [[7aw3]], [[7dxl]], [[7xhy]] - hTK Mer kinase domain (mutant) + inhibitor<br /> |
**[[7ab1]] - hTK Mer kinase domain + anti-cancer drug<br /> | **[[7ab1]] - hTK Mer kinase domain + anti-cancer drug<br /> | ||
**[[7aay]] - hTK Mer kinase domain (mutant) + anti-cancer drug<br /> | **[[7aay]] - hTK Mer kinase domain (mutant) + anti-cancer drug<br /> | ||
Line 472: | Line 481: | ||
*'''ErbB tyrosine kinase''' see [[Epidermal Growth Factor Receptor]] | *'''ErbB tyrosine kinase''' see [[Epidermal Growth Factor Receptor]] | ||
- | |||
- | *'''MuSK tyrosine kinase''' | ||
- | |||
- | **[[3hkl]] - rTK MuSK Fz-Crd domain <br /> | ||
- | **[[1luf]], [[2iep]] - rTK MuSK cytoplasmic domain <br /> | ||
*'''Sgk223 tyrosine kinase or sugen kinase''' | *'''Sgk223 tyrosine kinase or sugen kinase''' | ||
Line 485: | Line 489: | ||
**[[3us4]] - hTK Matk SH2 domain <br /> | **[[3us4]] - hTK Matk SH2 domain <br /> | ||
- | + | **[[1x6g]] - hTK Matk SH3 domain - NMR<br /> | |
- | + | ||
- | + | ||
- | **[[ | + | |
- | + | ||
- | + | ||
*'''Flt3 tyrosine kinase''' | *'''Flt3 tyrosine kinase''' | ||
**[[1rjb]] - hTK Flt3 kinase domain <br /> | **[[1rjb]] - hTK Flt3 kinase domain <br /> | ||
- | **[[4rt7]], [[ | + | **[[4rt7]], [[5x02]], [[6il3]] - hTK Flt3 kinase domain + inhibitor<br /> |
+ | **[[6jqr]] - hTK Flt3 kinase domain + leukemia drug<br / | ||
**[[4xuf]] - hTK Flt3 kinase domain (mutant) + leukemia drug<br /> | **[[4xuf]] - hTK Flt3 kinase domain (mutant) + leukemia drug<br /> | ||
+ | **[[3qs7]], [[3qs9]] - hTK Flt3 kinase domain + SL cytokine<br / | ||
*'''Tie2 tyrosine kinase''' | *'''Tie2 tyrosine kinase''' | ||
Line 502: | Line 503: | ||
**[[1fvr]] - hTK Tie2 kinase domain <br /> | **[[1fvr]] - hTK Tie2 kinase domain <br /> | ||
- | *''' | + | *'''DDR1 and DDR2 tyrosine kinase receptors''' see [[Epithelial discoidin domain-containing receptor]] |
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
- | + | ||
*'''c-Met tyrosine kinase''' see [[Hepatocyte growth factor receptor]] | *'''c-Met tyrosine kinase''' see [[Hepatocyte growth factor receptor]] | ||
Current revision
3D structures of tyrosine kinase
Updated on 01-March-2024 - For a general description of the protein see Tyrosine kinase