Tyrosine kinase 3D structures
From Proteopedia
(Difference between revisions)
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**[[1fyn]], [[4znx]] - hTK Fyn SH3 domain + peptide<br /> | **[[1fyn]], [[4znx]] - hTK Fyn SH3 domain + peptide<br /> | ||
| - | **[[ | + | **[[1a0n]], [[1azg]], [[1nyf]], [[1nyg]] - hTK Fyn SH3 domain + peptide – NMR<br /> |
| - | **[[ | + | **[[1avz]], [[1efn]] - hTK Fyn SH3 domain + HIV Nef protein<br /> |
**[[4d8d]], [[7d7s]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br /> | **[[4d8d]], [[7d7s]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br /> | ||
**[[1m27]] - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide<br /> | **[[1m27]] - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide<br /> | ||
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**[[5oaz]] - hTK SH3 domain <br /> | **[[5oaz]] - hTK SH3 domain <br /> | ||
| + | **[[7pw2]] - hTK SH3 domain (mutant) <br /> | ||
**[[1ju5]] - hTK SH3 domain (mutant) + CRK SH2 domain + phosphopeptide - NMR<br /> | **[[1ju5]] - hTK SH3 domain (mutant) + CRK SH2 domain + phosphopeptide - NMR<br /> | ||
**[[1awo]] - hTK SH3 domain + phosphopeptide – NMR<BR /> | **[[1awo]] - hTK SH3 domain + phosphopeptide – NMR<BR /> | ||
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**[[2o88]] - hTK SH3 domain (mutant} + peptide<br /> | **[[2o88]] - hTK SH3 domain (mutant} + peptide<br /> | ||
**[[4jjb]], [[4jjc]], [[4jjd]] - hTK abl SH3 domain <br /> | **[[4jjb]], [[4jjc]], [[4jjd]] - hTK abl SH3 domain <br /> | ||
| - | **[[ | + | **[[3eg0]], [[3eg1]], [[3eg2]], [[3eg3]], [[3egu]], [[4j9b]] - hTK abl SH3 domain (mutant)<br /> |
**[[4j9c]], [[4j9e]], [[4j9i]] - hTK abl SH3 domain (mutant) + p17 peptide<br /> | **[[4j9c]], [[4j9e]], [[4j9i]] - hTK abl SH3 domain (mutant) + p17 peptide<br /> | ||
**[[4j9d]], [[4j9f]] - hTK abl SH3 domain (mutant) + p0 peptide<br /> | **[[4j9d]], [[4j9f]] - hTK abl SH3 domain (mutant) + p0 peptide<br /> | ||
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**[[6xr6]], [[6xr7]], [[6xrg]] - hTK kinase domain (mutant) - NMR<br /> | **[[6xr6]], [[6xr7]], [[6xrg]] - hTK kinase domain (mutant) - NMR<br /> | ||
**[[2g1t]] - hTK kinase domain + peptide<br /> | **[[2g1t]] - hTK kinase domain + peptide<br /> | ||
| - | **[[ | + | **[[2g2f]], [[2g2i]] - hTK kinase domain (mutant) + peptide<br /> |
| - | **[[ | + | **[[2gqg]], [[2hzi]], [[2hz4]], [[2hz0]], [[2hyy]], [[3cs9]], [[3ue4]], [[4wa9]], [[7n9g]] - hTK kinase domain + cancer drug<br /> |
**[[2f4j]], [[4twp]] - hTK kinase domain (mutant) + cancer drug<br /> | **[[2f4j]], [[4twp]] - hTK kinase domain (mutant) + cancer drug<br /> | ||
| - | **[[ | + | **[[2e2b]], [[2hiw]], [[2v7a]], [[3qrk]], [[3qri]], [[3qrj]], [[4zog]], [[5hu9]], [[4yc8]], [[3pyy]], [[6npv]], [[6npu]], [[6npe]], [[7cc2]], [[7dt2]], [[7w7x]], [[7w7y]] - hTK kinase domain + inhibitor<br /> |
**[[1opj]], [[1opk]] - mTK kinase domain <br /> | **[[1opj]], [[1opk]] - mTK kinase domain <br /> | ||
**[[1fpu]], [[1m52]], [[2qoh]], [[3kf4]], [[3kfa]] - mTK kinase domain + inhibitor<br /> | **[[1fpu]], [[1m52]], [[2qoh]], [[3kf4]], [[3kfa]] - mTK kinase domain + inhibitor<br /> | ||
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**[[2kk1]] – hTK C terminal – NMR<BR /> | **[[2kk1]] – hTK C terminal – NMR<BR /> | ||
| - | |||
| - | *'''Anaplastic lymphoma kinase (Alk)''' or Alk tyrosine kinae receptor; Domains – Gly-rich 678-986; TG+EGF=like 648-1030; kinase 1093-1411 | ||
| - | |||
| - | **[[4tt7]], [[6cdt]] - hTK kinase domain<br /> | ||
| - | **[[3l9p]], [[3lcs]], [[3lct]], [[2yhv]], [[2yjr]], [[2yjs]], [[4fnw]], [[4fnx]], [[4anl]] - hTK kinase domain (mutant)<br /> | ||
| - | **[[7lrz]], [[7mzw]], [[7mzy]] - hTK Gly-rich domain<br /> | ||
| - | **[[7nx4]] - hTK TG+EGF-like domain<br /> | ||
| - | **[[7nx3]] - hTK TG+EGF-like domain + antibody<br /> | ||
| - | **[[2xb7]], [[2xba]], [[3aox]], [[5imx]], [[5kz0]], [[4ccb]], [[4ccu]], [[4cli]], [[4cmo]], [[4cmt]], [[4cmu]], [[4cnh]], [[4ctb]], [[4ctc]], [[6mx8]], [[6edl]], [[6ebw]], [[6e0r]], [[7btt]], [[7jy4]], [[7jyr]], [[7jys]], [[7jyt]] - hTK kinase domain + inhibitor<br /> | ||
| - | **[[4dce]], [[4fob]], [[4foc]], [[4fod]], [[4fny]], [[4fnz]], [[4joa]], [[4mkc]], [[4z55]], [[5iug]], [[5iuh]], [[5iui]], [[4cd0]], [[4clj]] - hTK kinase domain (mutant) + inhibitor<br /> | ||
| - | **[[2xp2]], [[5j7h]], [[5fto]], [[5ftq]] - hTK kinase domain + cancer drug<br /> | ||
| - | **[[2yfx]], [[4anq]], [[4ans]], [[5aaa]], [[5aab]], [[5aac]], [[5a9u]], [[5aa8]], [[5aa9]] - hTK kinase domain (mutant) + cancer drug<br /> | ||
| - | **[[7n00]], [[7nwz]]] - hTK kinase domain (mutant) + AUG-alpha<br /> | ||
| - | **[[7ls0]] - hTK kinase domain/AUG-alpha<br /> | ||
*'''Csk tyrosine kinase''' | *'''Csk tyrosine kinase''' | ||
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**[[3d7t]], [[3d7u]] - hTK kinase domain (mutant) + C-Src<br /> | **[[3d7t]], [[3d7u]] - hTK kinase domain (mutant) + C-Src<br /> | ||
**[[1k9a]] - TK C terminal - rat<br /> | **[[1k9a]] - TK C terminal - rat<br /> | ||
| + | |||
| + | *'''Fgr tyrosine kinase''' | ||
| + | |||
| + | **[[7uy0]] - hTK 80-527 + inhibitor<br /> | ||
| + | **[[7uy3]] - hTK 80-527 (mutant) + inhibitor<br /> | ||
| + | **[[7jt9]] - hTK SH3 domain 77-138<br /> | ||
*'''Jak tyrosine kinase''' see [[Janus kinase]] | *'''Jak tyrosine kinase''' see [[Janus kinase]] | ||
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**[[1spr]] - RsvTK + phosphate – Rous sarcoma virus<br /> | **[[1spr]] - RsvTK + phosphate – Rous sarcoma virus<br /> | ||
**[[2jyq]] – RsvTK – NMR<br /> | **[[2jyq]] – RsvTK – NMR<br /> | ||
| - | **[[1kc2]], [[ | + | **[[1kc2]], [[1is0]], [[1nzl]], [[1nzv]], [[1sps]] - RsvTK + peptide<br /> |
**[[1sha]], [[1shb]] - RsvTK + phosphopeptide<br /> | **[[1sha]], [[1shb]] - RsvTK + phosphopeptide<br /> | ||
**[[1qwe]], [[1qwf]] - RsvTK + peptide<br /> | **[[1qwe]], [[1qwf]] - RsvTK + peptide<br /> | ||
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**[[1srl]], [[1srm]] - cTK – NMR<br /> | **[[1srl]], [[1srm]] - cTK – NMR<br /> | ||
**[[3fj5]], [[4jz3]], [[4jz4]], [[6xvo]], [[6xvn]] - cTK<br /> | **[[3fj5]], [[4jz3]], [[4jz4]], [[6xvo]], [[6xvn]] - cTK<br /> | ||
| - | **[[4le9]], [[4oml]], [[4omm]], [[4omn]], [[4omo]], [[4omp]], [[4omq]], [[ | + | **[[4le9]], [[4oml]], [[4omm]], [[4omn]], [[4omo]], [[4omp]], [[4omq]], [[4rtu]], [[4rtx]], [[5i11]], [[7a30]], [[7a31]], [[7a32]], [[7a33]], [[7a34]], [[7a35]], [[7a36]], [[7a37]], [[7a38]], [[7a39]], [[7a3a]], [[7a3b]], [[7a3c]], [[7a3d]], [[7a3e]], [[7ner]], [[7nes]], [[7net]] - cTK (mutant) <br /> |
**[[6xx3]], [[6xx2]], [[6xx5]], [[6xx4]], [[6xx5]], [[6xx2]] - cTK (mutant) + ion<br /> | **[[6xx3]], [[6xx2]], [[6xx5]], [[6xx4]], [[6xx5]], [[6xx2]] - cTK (mutant) + ion<br /> | ||
| - | **[[ | + | **[[2pri]], [[4hxj]], [[4qt7]], [[4rty]], [[4rtz]] - cTK + peptide<br /> |
**[[1prm]], [[1rlp]], [[1rlq]], [[1nlo]], [[1nlp]] - cTK + peptide - NMR<br /> | **[[1prm]], [[1rlp]], [[1rlq]], [[1nlo]], [[1nlp]] - cTK + peptide - NMR<br /> | ||
**[[4hvu]], [[4hvv]], [[4hvw]], [[4rtv]], [[4rtw]], [[5ob2]], [[5ob1]], [[5ob0]], [[5oav]] - cTK (mutant) + peptide<br /> | **[[4hvu]], [[4hvv]], [[4hvw]], [[4rtv]], [[4rtw]], [[5ob2]], [[5ob1]], [[5ob0]], [[5oav]] - cTK (mutant) + peptide<br /> | ||
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**[[1x27]] - hTK Lck SH3-SH2 domain + peptide<br /> | **[[1x27]] - hTK Lck SH3-SH2 domain + peptide<br /> | ||
**[[1qpj]] - hTK Lck kinase domain + staurosporin<br /> | **[[1qpj]] - hTK Lck kinase domain + staurosporin<br /> | ||
| - | **[[ | + | **[[1qpc]], [[1qpd]], [[1qpe]], [[2of2]], [[2of4]], [[2ofu]], [[2ofv]], [[2og8]], [[2zm1]], [[2zm4]], [[2zyb]], [[3ac1]], [[3ac2]], [[3ac3]], [[3ac4]], [[3ac5]], [[3ac8]], [[3acj]], [[3ack]], [[3ad4]], [[3ad5]], [[3ad6]], [[3b2w]], [[3bym]], [[3bys]], [[3byu]], [[3byo]], [[3kmm]], [[6pdj]] - hTK Lck kinase domain + inhibitor<br /> |
**[[3mpm]] - hTK Lck kinase domain (mutant) + inhibitor<br /> | **[[3mpm]] - hTK Lck kinase domain (mutant) + inhibitor<br /> | ||
**[[4c3f]] - hTK Lck kinase domain (mutant) + chemotype<br /> | **[[4c3f]] - hTK Lck kinase domain (mutant) + chemotype<br /> | ||
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**[[1xbb]] - hSyk kinase domain + Gleevec<br /> | **[[1xbb]] - hSyk kinase domain + Gleevec<br /> | ||
**[[1xbc]] - hSyk kinase domain + staurosporine<br /> | **[[1xbc]] - hSyk kinase domain + staurosporine<br /> | ||
| - | **[[3emg]], [[3fqe]], [[3fqh]], [[3fqs]], [[3srv]], [[ | + | **[[3emg]], [[3fqe]], [[3fqh]], [[3fqs]], [[3srv]], [[3tub]], [[3tuc]], [[3tud]], [[3vf8]], [[3vf9]], [[4dfl]], [[4dfn]], [[4f4p]], [[4fyn]], [[4fyo]], [[4fz6]], [[4fz7]], [[4gfg]], [[4i0r]], [[4i0s]], [[4i0t]], [[4puz]], [[4pv0]], [[4rx7]], [[4rx8]], [[4rx9]], [[4wnm]], [[4xg3]], [[4xg4]], [[4xg6]], [[4xg7]], [[4xg8]], [[4xg9]], [[4rss]], [[4yjo]], [[4yjp]], [[4yjq]], [[4yjr]], [[4yjs]], [[4yjt]], [[4yju]], [[4yjv]], [[5c26]], [[5c27]], [[5ghv]], [[5lma]], [[5lmb]], [[5tr6]], [[5tt7]], [[5tiu]], [[5t68]], [[5y5t]], [[5y5u]], [[6hm6]], [[6hm7]], [[6vov]], [[6zc0]], [[6zcp]], [[6zcq]], [[6zcr]], [[6zcs]], [[6zcu]], [[6zcx]], [[6zcy]], [[8bi2]] - hSyk kinase domain + inhibitor<br /> |
**[[4px6]], [[5cxh]], [[5cxz]], [[5cy3]] - hSyk kinase domain (mutant) + inhibitor<br /> | **[[4px6]], [[5cxh]], [[5cxz]], [[5cy3]] - hSyk kinase domain (mutant) + inhibitor<br /> | ||
**[[1csy]], [[1csz]] - hSyk SH2 domain + phosphopeptide – NMR<BR /> | **[[1csy]], [[1csz]] - hSyk SH2 domain + phosphopeptide – NMR<BR /> | ||
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**[[3fzp]] - hTK Pyk2 kinase domain + ATPγS<br /> | **[[3fzp]] - hTK Pyk2 kinase domain + ATPγS<br /> | ||
| - | **[[ | + | **[[3et7]], [[3fzr]], [[3fzs]], [[3fzt]], [[3h3c]], [[4h1j]], [[4h1m]], [[5to8]], [[5tob]] - hTK Pyk2 kinase domain + inhibitor<br /> |
**[[3gm1]], [[4r32]] - hTK Pyk2 FAT domain + paxillin peptide<br /> | **[[3gm1]], [[4r32]] - hTK Pyk2 FAT domain + paxillin peptide<br /> | ||
| - | **[[ | + | **[[4xef]], [[4xek]], [[4xev]] - hTK Pyk2 FAT domain + leupaxin peptide<br /> |
**[[4h1j]] - hFAK2 kinase domain + pyrazole inhibitor<br /> | **[[4h1j]] - hFAK2 kinase domain + pyrazole inhibitor<br /> | ||
**[[3h3c]] - hFAK2 kinase domain + pyrimidine inhibitor<br /> | **[[3h3c]] - hFAK2 kinase domain + pyrimidine inhibitor<br /> | ||
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**[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br /> | **[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br /> | ||
**[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br /> | **[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br /> | ||
| + | |||
| + | *'''Ptk7 tyrosine kinase or inactive tyrosine-protein kinase 7''' | ||
| + | |||
| + | **[[6vg3]] - hTK Ptk7 kinase domain <br /> | ||
*'''PtkA tyrosine kinase''' | *'''PtkA tyrosine kinase''' | ||
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*'''Ack1 tyrosine kinase''' or activated cdc42 kinase 1 | *'''Ack1 tyrosine kinase''' or activated cdc42 kinase 1 | ||
| - | **[[1u46]], [[4hzr]] - hTK Ack1 kinase domain <br /> | + | **[[1u46]], [[4hzr]] - hTK Ack1 kinase domain 115-389<br /> |
**[[4hzs]] - hTK Ack1 kinase+SH3 domains <br /> | **[[4hzs]] - hTK Ack1 kinase+SH3 domains <br /> | ||
| - | **[[1u4d]], [[3eqp]], [[3eqr]], [[4ewh]], [[4id7]], [[5zxb]] - hTK Ack1 kinase domain + inhibitor<br /> | + | **[[1u4d]], [[3eqp]], [[3eqr]], [[4ewh]], [[4id7]], [[5zxb]], [[7kp6]], [[8hmt]] - hTK Ack1 kinase domain + inhibitor<br /> |
| + | **[[8fe9]] - hTK Ack1 kinase domain (mutant) + inhibitor<br /> | ||
| + | |||
*'''RECEPTOR TYROSINE KINASES - RTK''' | *'''RECEPTOR TYROSINE KINASES - RTK''' | ||
| - | * | + | *Burton’s tyrosine kinase (Domains: PH 1-170; SH3 216-273; SH2 273-378; kinase 378-659) |
| + | **[[8gmb]] - hTK Btk <br /> | ||
**[[2z0p]] - hTK Btk PH domain<br /> | **[[2z0p]] - hTK Btk PH domain<br /> | ||
**[[1btk]] – hTK Btk PH domain (mutant) <br /> | **[[1btk]] – hTK Btk PH domain (mutant) <br /> | ||
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**[[4xi2]] - hTK Btk SH3-SH2-kinase domain<br /> | **[[4xi2]] - hTK Btk SH3-SH2-kinase domain<br /> | ||
**[[4y95]] - bTK Btk kinase domain (mutant) - bovine<br /> | **[[4y95]] - bTK Btk kinase domain (mutant) - bovine<br /> | ||
| - | **[[4y93]] - bTK Btk PH+kinase domains (mutant) <br /> | + | **[[4y93]], [[8s93]] - bTK Btk PH+kinase domains (mutant) <br /> |
*Btk complex | *Btk complex | ||
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**[[1bwn]] - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate<br /> | **[[1bwn]] - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate<br /> | ||
**[[6yyf]], [[6yyg]], [[6yyk]] - hTK Btk PH domain (mutant) + inhibitor<br /> | **[[6yyf]], [[6yyg]], [[6yyk]] - hTK Btk PH domain (mutant) + inhibitor<br /> | ||
| - | **[[3gen]], [[3ocs]], [[3pix]], [[3piy]], [[3piz]], [[3pj1]], [[3pj2]], [[3pj3]], [[4nwm]], [[ | + | **[[3gen]], [[3ocs]], [[3pix]], [[3piy]], [[3piz]], [[3pj1]], [[3pj2]], [[3pj3]], [[4nwm]], [[4rx5]], [[4yhf]], [[4z3v]], [[4zly]], [[4zlz]], [[5bpy]], [[5bq0]], [[5fbn]], [[5fbo]], [[5j87]], [[5jrs]], [[5kup]], [[5p9f]], [[5p9g]], [[5p9h]], [[5p9i]], [[5p9j]], [[5p9k]], [[5p9l]], [[5p9m]], [[5t18]], [[5u9d]], [[5vfi]], [[5vgo]], [[5xyz]], [[5zz4]], [[6aua]], [[6aub]], [[6bik]], [[6bke]], [[6bkh]], [[6bkw]], [[6bln]], [[6di0]], [[6di1]], [[6di3]], [[6di5]], [[6di9]], [[6e4f]], [[6e9p]], [[6n9p]], [[6nzm]], [[6nfh]], [[6nfi]], [[6o8i]], [[6s90]], [[6tfp]], [[6vxq]], [[6w06]], [[6w07]], [[6x3n]], [[6x3o]], [[6x3p]], [[6xe4]], [[7kxl]], [[7kxm]], [[7kxn]], [[7kxo]], [[7kxp]], [[7kxq]], [[7lty]], [[7ltz]], [[7n4q]], [[7n4r]], [[7n4s]], [[7n5o]], [[7n5r]], [[7n5x]], [[7n5y]], [[7r60]], [[7r61]], [[7yc9]], [[8e2m]], [[8ejb]], [[8flg]], [[8flh]], [[8flv]], [[8gc7]] - hTK Btk kinase domain + inhibitor<br /> |
| - | **[[3k54]], [[3t9t]], [[4ot5]], [[4ot6]], [[4otq]], [[4otr]], [[4otf]], [[4rfy]], [[4rfz]], [[4rg0]], [[6ep9]], [[6hrt]], [[6hrp]] - hTK Btk kinase domain (mutant) + inhibitor<br /> | + | **[[3k54]], [[3t9t]], [[4ot5]], [[4ot6]], [[4otq]], [[4otr]], [[4otf]], [[4rfy]], [[4rfz]], [[4rg0]], [[6ep9]], [[6hrt]], [[6hrp]], [[8ff0]], [[8gc8]] - hTK Btk kinase domain (mutant) + inhibitor<br /> |
| - | **[[6w7o]], [[6w8i]] - hTK Btk kinase domain + cIAP + inhibitor<br /> | + | **[[6w7o]], [[6w8i]], [[8dso]] - hTK Btk kinase domain + cIAP + inhibitor<br /> |
| - | **[[5vgo]] - hTK Btk kinase domain + cancer drug<br /> | + | **[[5vgo]], [[7l5o]], [[7l5p]], [[8fll]], [[8u2d]], [[8u2e]] - hTK Btk kinase domain + cancer drug<br /> |
| - | **[[3oct]] - hTK Btk kinase domain (mutant) + cancer drug<br /> | + | **[[3oct]], [[8fd9]], [[8fln]] - hTK Btk kinase domain (mutant) + cancer drug<br /> |
**[[6omu]] - hTK Btk kinase domain + MS drug<br /> | **[[6omu]] - hTK Btk kinase domain + MS drug<br /> | ||
**[[6j6m]] - hTK Btk kinase domain + MCL drug<br /> | **[[6j6m]] - hTK Btk kinase domain + MCL drug<br /> | ||
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**[[2e9w]] - hTK Kit extracellular domain + stem cell factor<br /> | **[[2e9w]] - hTK Kit extracellular domain + stem cell factor<br /> | ||
**[[1t45]], [[4pgz]] - hTK Kit kinase domain<br /> | **[[1t45]], [[4pgz]] - hTK Kit kinase domain<br /> | ||
| - | **[[1t46]], [[4u0i]], [[ | + | **[[1t46]], [[4u0i]], [[6kia]], [[6mob]] - hTK Kit kinase domain + cancer drug<br /> |
| - | **[[6gqj]], [[ | + | **[[6gqj]], [[6gqk]], [[6gql]], [[6gqm]] - hTK Kit kinase domain (mutant) + cancer drug<br /> |
**[[6itv]], [[6itt]], [[6xv9]], [[6xva]], [[6xvb]], [[7khg]], [[7khj]], [[7khk]] - hTK Kit kinase domain + inhibitor<br /> | **[[6itv]], [[6itt]], [[6xv9]], [[6xva]], [[6xvb]], [[7khg]], [[7khj]], [[7khk]] - hTK Kit kinase domain + inhibitor<br /> | ||
**[[4hvs]], [[6hh1]] - hTK Kit kinase domain (mutant) + inhibitor<br /> | **[[4hvs]], [[6hh1]] - hTK Kit kinase domain (mutant) + inhibitor<br /> | ||
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**[[2dbj]] - hTK Mer FN3 domain – NMR<BR /> | **[[2dbj]] - hTK Mer FN3 domain – NMR<BR /> | ||
| - | **[[2p0c]] - hTK Mer kinase domain | + | **[[2p0c]] - hTK Mer kinase domain<br /> |
*Mer complex | *Mer complex | ||
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**[[3brb]] - hTK Mer kinase domain + ADP<br /> | **[[3brb]] - hTK Mer kinase domain + ADP<br /> | ||
**[[2p0c]] - hTK Mer kinase domain + ANP<br /> | **[[2p0c]] - hTK Mer kinase domain + ANP<br /> | ||
| - | **[[3bpr]], [[3tcp]], [[4m3q]], [[4mh7]], [[4mha]], [[ | + | **[[3bpr]], [[3tcp]], [[4m3q]], [[4mh7]], [[4mha]], [[5k0k]], [[5k0x]], [[5tc0]], [[5td2]], [[5u6c]], [[6mep]], [[7avx]], [[7aw4]], [[7cqe]], [[7m5z]], [[7oam]], [[7ols]], [[7olv]], [[7olx]] - hTK Mer kinase domain + inhibitor<br /> |
| - | **[[7ab2]], [[7aax]], [[7aaz]] - hTK Mer kinase domain (mutant) + inhibitor<br /> | + | **[[7ab2]], [[7aax]], [[7aaz]], [[7avy]], [[7avz]], [[7aw0]], [[7aw1]], [[7aw2]], [[7aw3]], [[7dxl]], [[7xhy]] - hTK Mer kinase domain (mutant) + inhibitor<br /> |
**[[7ab1]] - hTK Mer kinase domain + anti-cancer drug<br /> | **[[7ab1]] - hTK Mer kinase domain + anti-cancer drug<br /> | ||
**[[7aay]] - hTK Mer kinase domain (mutant) + anti-cancer drug<br /> | **[[7aay]] - hTK Mer kinase domain (mutant) + anti-cancer drug<br /> | ||
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*'''ErbB tyrosine kinase''' see [[Epidermal Growth Factor Receptor]] | *'''ErbB tyrosine kinase''' see [[Epidermal Growth Factor Receptor]] | ||
| - | |||
| - | *'''MuSK tyrosine kinase''' | ||
| - | |||
| - | **[[3hkl]] - rTK MuSK Fz-Crd domain <br /> | ||
| - | **[[1luf]], [[2iep]] - rTK MuSK cytoplasmic domain <br /> | ||
*'''Sgk223 tyrosine kinase or sugen kinase''' | *'''Sgk223 tyrosine kinase or sugen kinase''' | ||
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**[[1rjb]] - hTK Flt3 kinase domain <br /> | **[[1rjb]] - hTK Flt3 kinase domain <br /> | ||
| - | **[[4rt7]], [[ | + | **[[4rt7]], [[5x02]], [[6il3]] - hTK Flt3 kinase domain + inhibitor<br /> |
**[[6jqr]] - hTK Flt3 kinase domain + leukemia drug<br / | **[[6jqr]] - hTK Flt3 kinase domain + leukemia drug<br / | ||
**[[4xuf]] - hTK Flt3 kinase domain (mutant) + leukemia drug<br /> | **[[4xuf]] - hTK Flt3 kinase domain (mutant) + leukemia drug<br /> | ||
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**[[1fvr]] - hTK Tie2 kinase domain <br /> | **[[1fvr]] - hTK Tie2 kinase domain <br /> | ||
| - | |||
| - | *'''Ret tyrosine kinase''' or proto-oncogene tyrosine protein kinase receptor Ret | ||
| - | |||
| - | **[[6nja]] - hTK Ret kinase domain<br /> | ||
| - | **[[6fek]] - hTK Ret kinase domain (mutant)<br /> | ||
| - | **[[5amn]], [[6vhg]], [[7run]] - hTK Ret kinase domain + inhibitor<br /> | ||
| - | **[[6i83]], [[6i82]] - hTK Ret kinase domain (mutant) + inhibitor<br /> | ||
| - | **[[6nec]], [[6ne7]], [[7ju5]] | ||
| - | - hTK Ret kinase domain + cancer drug<br /> | ||
| - | **[[4ux8]] - hTK Ret extracellular domain + GFR alpha 1<br /> | ||
*'''DDR1 and DDR2 tyrosine kinase receptors''' see [[Epithelial discoidin domain-containing receptor]] | *'''DDR1 and DDR2 tyrosine kinase receptors''' see [[Epithelial discoidin domain-containing receptor]] | ||
Current revision
3D structures of tyrosine kinase
Updated on 01-March-2024 - For a general description of the protein see Tyrosine kinase
