This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8p64
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8p64 is ON HOLD Authors: Plewka, J., Magiera-Mularz, K., van der Straat, R., Draijer, R., Surmiak, E., Butera, R., Land, L., Musielak, B., Domling, ...) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of PD-L1 with low molecular weight inhibitor== | |
| - | + | <StructureSection load='8p64' size='340' side='right'caption='[[8p64]], [[Resolution|resolution]] 3.31Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8p64]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P64 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.312Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X1Q:~{N}-[[1-[(~{E})-2-(2-methyl-3-phenyl-phenyl)ethenyl]-1,2,3,4-tetrazol-5-yl]methyl]ethanamine'>X1Q</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p64 OCA], [https://pdbe.org/8p64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p64 RCSB], [https://www.ebi.ac.uk/pdbsum/8p64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p64 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: Magiera-Mularz | + | <references/> |
| - | [[Category: Musielak | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Van | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Butera R]] | ||
| + | [[Category: Domling A]] | ||
| + | [[Category: Draijer R]] | ||
| + | [[Category: Land L]] | ||
| + | [[Category: Magiera-Mularz K]] | ||
| + | [[Category: Musielak B]] | ||
| + | [[Category: Plewka J]] | ||
| + | [[Category: Surmiak E]] | ||
| + | [[Category: Van der Straat R]] | ||
Current revision
Co-crystal structure of PD-L1 with low molecular weight inhibitor
| |||||||||||
