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1s12

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[[Image:1s12.gif|left|200px]]<br /><applet load="1s12" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1s12, resolution 2.00&Aring;" />
 
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'''Crystal structure of TM1457'''<br />
 
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==Overview==
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==Crystal structure of TM1457==
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The crystal structure of a hypothetical protein, TM1457, from Thermotoga, maritima has been determined at 2.0A resolution. TM1457 belongs to the, DUF464 family (57 members) for which there is no known function. The, structure shows that it is composed of two helices in contact with one, side of a five-stranded beta-sheet. Two identical monomers form a, pseudo-dimer in the asymmetric unit. There is a large cleft between the, first alpha-helix and the second beta-strand. This cleft may be, functionally important, since the two highly conserved motifs, GHA and, VCAXV(S/T), are located around the cleft. A structural comparison of, TM1457 with known protein structures shows the best hit with another, hypothetical protein, Ybl001C from Saccharomyces cerevisiae, though they, share low structural similarity. Therefore, TM1457 still retains a unique, topology and reveals a novel fold.
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<StructureSection load='1s12' size='340' side='right'caption='[[1s12]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1s12]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S12 FirstGlance]. <br>
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1S12 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=ACT:'>ACT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S12 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s12 OCA], [https://pdbe.org/1s12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s12 RCSB], [https://www.ebi.ac.uk/pdbsum/1s12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s12 ProSAT], [https://www.topsan.org/Proteins/BSGC/1s12 TOPSAN]</span></td></tr>
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Crystal structure of TM1457 from Thermotoga maritima., Shin DH, Lou Y, Jancarik J, Yokota H, Kim R, Kim SH, J Struct Biol. 2005 Nov;152(2):113-7. Epub 2005 Oct 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16242963 16242963]
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</table>
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[[Category: Single protein]]
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== Function ==
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[https://www.uniprot.org/uniprot/Q9X1G8_THEMA Q9X1G8_THEMA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s12_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s12 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: BSGC, Berkeley.Structural.Genomics.Center.]]
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[[Category: Jancarik J]]
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[[Category: Jancarik, J.]]
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[[Category: Kim R]]
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[[Category: Kim, R.]]
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[[Category: Kim S-H]]
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[[Category: Kim, S.H.]]
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[[Category: Lou Y]]
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[[Category: Lou, Y.]]
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[[Category: Shin DH]]
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[[Category: Shin, D.H.]]
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[[Category: Yokota H]]
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[[Category: Yokota, H.]]
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[[Category: ACT]]
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[[Category: berkeley structural genomics center]]
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[[Category: bsgc]]
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[[Category: crystal]]
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[[Category: hypothetical protein]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:23:13 2008''
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Current revision

Crystal structure of TM1457

PDB ID 1s12

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