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2jh8

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[[Image:2jh8.gif|left|200px]]
 
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{{Structure
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==The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line==
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|PDB= 2jh8 |SIZE=350|CAPTION= <scene name='initialview01'>2jh8</scene>, resolution 3.22&Aring;
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<StructureSection load='2jh8' size='340' side='right'caption='[[2jh8]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Gun+Binding+Site+For+Chain+A'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE'>M7G</scene> and <scene name='pdbligand=GUN:GUANINE'>GUN</scene>
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<table><tr><td colspan='2'>[[2jh8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bluetongue_virus_(serotype_10_/_American_isolate) Bluetongue virus (serotype 10 / American isolate)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JH8 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.22&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jh8 OCA], [https://pdbe.org/2jh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jh8 RCSB], [https://www.ebi.ac.uk/pdbsum/2jh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jh8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q65751_BTV1X Q65751_BTV1X] The VP4 protein is one of the five proteins (with VP1, VP3, VP6 and VP7) which form the inner capsid of the virus.[ARBA:ARBA00002541]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jh8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jh8 ConSurf].
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<div style="clear:both"></div>
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'''THE STRUCTURE OF BLUETONGUE VIRUS VP4 REVEALS A MULTIFUNCTIONAL RNA-CAPPING PRODUCTION-LINE'''
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.
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[[Category: Large Structures]]
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[[Category: Grimes JM]]
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==About this Structure==
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[[Category: Roy P]]
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2JH8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bluetongue_virus_10_(isolate_usa) Bluetongue virus 10 (isolate usa)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JH8 OCA].
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[[Category: Stuart DI]]
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[[Category: Sutton G]]
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==Reference==
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Bluetongue virus VP4 is an RNA-capping assembly line., Sutton G, Grimes JM, Stuart DI, Roy P, Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17417654 17417654]
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[[Category: Bluetongue virus 10 (isolate usa)]]
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[[Category: Single protein]]
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[[Category: Grimes, J M.]]
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[[Category: Roy, P.]]
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[[Category: Stuart, D I.]]
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[[Category: Sutton, G.]]
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[[Category: GUN]]
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[[Category: M7G]]
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[[Category: core protein]]
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[[Category: guanylyltransferase]]
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[[Category: methyltransferase]]
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[[Category: viral capping enzyme]]
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[[Category: viral protein]]
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[[Category: virion protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:41:53 2008''
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Current revision

The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line

PDB ID 2jh8

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