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4qci
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PDGF-B blocking antibody bound to PDGF-BB== | |
| + | <StructureSection load='4qci' size='340' side='right'caption='[[4qci]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4qci]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QCI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qci OCA], [https://pdbe.org/4qci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qci RCSB], [https://www.ebi.ac.uk/pdbsum/4qci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qci ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN] Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.<ref>PMID:12660034</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN] Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Antibody 3D structures|Antibody 3D structures]] | |
| - | + | *[[3D structures of human antibody|3D structures of human antibody]] | |
| - | [[Category: | + | == References == |
| - | [[Category: Carven | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Pullen | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Carven G]] |
| + | [[Category: Kuai J]] | ||
| + | [[Category: LaVallie E]] | ||
| + | [[Category: Mosyak L]] | ||
| + | [[Category: Pullen N]] | ||
| + | [[Category: Tam M]] | ||
Current revision
PDGF-B blocking antibody bound to PDGF-BB
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Categories: Homo sapiens | Large Structures | Carven G | Kuai J | LaVallie E | Mosyak L | Pullen N | Tam M
