4z8c
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin== | |
| + | <StructureSection load='4z8c' size='340' side='right'caption='[[4z8c]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4z8c]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z8C FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4SU:4-THIOURIDINE-5-MONOPHOSPHATE'>4SU</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z8c OCA], [https://pdbe.org/4z8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z8c RCSB], [https://www.ebi.ac.uk/pdbsum/4z8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z8c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RL2_THET8 RL2_THET8] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial (By similarity). Makes several contacts with the 16S rRNA (forming bridge B7b) in the 70S ribosome.[HAMAP-Rule:MF_01320_B] | ||
| - | + | ==See Also== | |
| - | + | *[[Ribosomal protein THX 3D structures|Ribosomal protein THX 3D structures]] | |
| - | + | *[[Ribosome 3D structures|Ribosome 3D structures]] | |
| - | [[Category: | + | *[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]] |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Gagnon | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Thermus thermophilus HB8]] |
| + | [[Category: Gagnon MG]] | ||
| + | [[Category: Lomakin IB]] | ||
| + | [[Category: Roy RN]] | ||
| + | [[Category: Steitz TA]] | ||
Current revision
Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin
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