4z8d
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Antibacterial FabH Inhibitors with Validated Mode of Action in Haemophilus Influenzae by in vitro resistance mutation mapping== | |
| + | <StructureSection load='4z8d' size='340' side='right'caption='[[4z8d]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4z8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z8D FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4LB:TRANS-4-[({[(2-CHLOROBENZYL)OXY]CARBONYL}AMINO)METHYL]CYCLOHEXANECARBOXYLIC+ACID'>4LB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z8d OCA], [https://pdbe.org/4z8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z8d RCSB], [https://www.ebi.ac.uk/pdbsum/4z8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z8d ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FABH_ECOLI FABH_ECOLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain.[HAMAP-Rule:MF_01815] | ||
| - | + | ==See Also== | |
| - | + | *[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Lahiri | + | [[Category: Escherichia coli O157:H7]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lahiri SD]] | ||
Current revision
Antibacterial FabH Inhibitors with Validated Mode of Action in Haemophilus Influenzae by in vitro resistance mutation mapping
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