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4znb

From Proteopedia

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{{Seed}}
 
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[[Image:4znb.png|left|200px]]
 
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<!--
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==METALLO-BETA-LACTAMASE (C181S MUTANT)==
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The line below this paragraph, containing "STRUCTURE_4znb", creates the "Structure Box" on the page.
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<StructureSection load='4znb' size='340' side='right'caption='[[4znb]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4znb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_fragilis Bacteroides fragilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZNB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_4znb| PDB=4znb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4znb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4znb OCA], [https://pdbe.org/4znb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4znb RCSB], [https://www.ebi.ac.uk/pdbsum/4znb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4znb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAB_BACFG BLAB_BACFG] Can hydrolyze carbapenem compounds.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zn/4znb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4znb ConSurf].
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<div style="clear:both"></div>
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===METALLO-BETA-LACTAMASE (C181S MUTANT)===
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10210203}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10210203 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10210203}}
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==About this Structure==
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4ZNB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteroides_fragilis Bacteroides fragilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZNB OCA].
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==Reference==
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Structural consequences of the active site substitution Cys181 ==&gt; Ser in metallo-beta-lactamase from Bacteroides fragilis., Li Z, Rasmussen BA, Herzberg O, Protein Sci. 1999 Jan;8(1):249-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10210203 10210203]
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[[Category: Bacteroides fragilis]]
[[Category: Bacteroides fragilis]]
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Herzberg O]]
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[[Category: Herzberg, O.]]
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[[Category: Li Z]]
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[[Category: Li, Z.]]
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[[Category: Beta-lactamase]]
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[[Category: Cadmium]]
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[[Category: Hydrolase]]
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[[Category: Metallo beta-lactamase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:55:10 2008''
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Current revision

METALLO-BETA-LACTAMASE (C181S MUTANT)

PDB ID 4znb

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