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4zra

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==CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LPRG BINDING TO TRIACYLGLYCERIDE==
==CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LPRG BINDING TO TRIACYLGLYCERIDE==
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<StructureSection load='4zra' size='340' side='right' caption='[[4zra]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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<StructureSection load='4zra' size='340' side='right'caption='[[4zra]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zra]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zra]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZRA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4RF:TRIPALMITOYLGLYCEROL'>4RF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mh8|3mh8]], [[3mha|3mha]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4RF:TRIPALMITOYLGLYCEROL'>4RF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zra OCA], [http://pdbe.org/4zra PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zra RCSB], [http://www.ebi.ac.uk/pdbsum/4zra PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zra OCA], [https://pdbe.org/4zra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zra RCSB], [https://www.ebi.ac.uk/pdbsum/4zra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zra ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LPRG_MYCTU LPRG_MYCTU]] TLR2 agonist that can inhibit primary human macrophage MHC-II Ag processing. Required for Rv1410c (P55) activity.<ref>PMID:15294983</ref> <ref>PMID:18156250</ref>
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[https://www.uniprot.org/uniprot/LPRG_MYCTU LPRG_MYCTU] TLR2 agonist that can inhibit primary human macrophage MHC-II Ag processing. Required for Rv1410c (P55) activity.<ref>PMID:15294983</ref> <ref>PMID:18156250</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mycobacterium tuberculosis (Mtb) mutants lacking rv1411c, which encodes the lipoprotein LprG, and rv1410c, which encodes a putative efflux pump, are dramatically attenuated for growth in mice. Here we show that loss of LprG-Rv1410 in Mtb leads to intracellular triacylglyceride (TAG) accumulation, and overexpression of the locus increases the levels of TAG in the culture medium, demonstrating a role of this locus in TAG transport. LprG binds TAG within a large hydrophobic cleft and is sufficient to transfer TAG from donor to acceptor membranes. Further, LprG-Rv1410 is critical for broadly regulating bacterial growth and metabolism in vitro during carbon restriction and in vivo during infection of mice. The growth defect in mice is due to disrupted bacterial metabolism and occurs independently of key immune regulators. The in vivo essentiality of this locus suggests that this export system and other regulators of metabolism should be considered as targets for novel therapeutics.
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Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis.,Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ PLoS Pathog. 2016 Jan 11;12(1):e1005351. doi: 10.1371/journal.ppat.1005351., eCollection 2016 Jan. PMID:26751071<ref>PMID:26751071</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4zra" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Annand, J]]
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[[Category: Large Structures]]
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[[Category: Bai, L]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Cheng, T Y]]
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[[Category: Annand J]]
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[[Category: Farrow, M]]
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[[Category: Bai L]]
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[[Category: Hussain, M]]
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[[Category: Cheng TY]]
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[[Category: Iqbal, J]]
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[[Category: Farrow M]]
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[[Category: Layre, E]]
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[[Category: Hussain M]]
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[[Category: Martinot, A J]]
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[[Category: Iqbal J]]
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[[Category: Moody, D B]]
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[[Category: Layre E]]
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[[Category: Rubin, E J]]
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[[Category: Martinot AJ]]
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[[Category: Sacchettini, J]]
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[[Category: Moody DB]]
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[[Category: Seeliger, J]]
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[[Category: Rubin EJ]]
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[[Category: Sullivan, Z]]
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[[Category: Sacchettini J]]
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[[Category: Structural genomic]]
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[[Category: Seeliger J]]
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[[Category: Tsai, J H.C]]
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[[Category: Sullivan Z]]
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[[Category: Lipid binding protein]]
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[[Category: Tsai JHC]]
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[[Category: Lipoprotein]]
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[[Category: Lprg]]
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[[Category: Tbsgc]]
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Current revision

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LPRG BINDING TO TRIACYLGLYCERIDE

PDB ID 4zra

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