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5bqd

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'''Unreleased structure'''
 
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The entry 5bqd is ON HOLD until Paper Publication
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==Crystal Structure of TBX5 (1-239) Dimer==
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<StructureSection load='5bqd' size='340' side='right'caption='[[5bqd]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5bqd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BQD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.583&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bqd OCA], [https://pdbe.org/5bqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bqd RCSB], [https://www.ebi.ac.uk/pdbsum/5bqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bqd ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN] Holt-Oram syndrome. The disease is caused by mutations affecting the gene represented in this entry. Defects in TBX5 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN] DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref> <ref>PMID:8988164</ref>
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Authors: Pradhan, L., Gopal, S., Patel, A., Kasahara, H., Nam, H.J.
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==See Also==
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*[[T-box proteins|T-box proteins]]
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Description: Crystal Structure of TBX5 (1-239) Dimer
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Pradhan, L]]
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__TOC__
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[[Category: Nam, H.J]]
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</StructureSection>
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[[Category: Gopal, S]]
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[[Category: Homo sapiens]]
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[[Category: Kasahara, H]]
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[[Category: Large Structures]]
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[[Category: Patel, A]]
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[[Category: Gopal S]]
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[[Category: Kasahara H]]
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[[Category: Nam HJ]]
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[[Category: Patel A]]
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[[Category: Pradhan L]]

Current revision

Crystal Structure of TBX5 (1-239) Dimer

PDB ID 5bqd

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