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5ctc

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(New page: '''Unreleased structure''' The entry 5ctc is ON HOLD Authors: Vajdos, F.F. Description: Humanized yeast ACC carboxyltransferase domain bound to {4-[3-(6,7-DIETHOXY-QUINAZOLIN-4-YLAMINO...)
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'''Unreleased structure'''
 
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The entry 5ctc is ON HOLD
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==Humanized yeast ACC carboxyltransferase domain bound to tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate==
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<StructureSection load='5ctc' size='340' side='right'caption='[[5ctc]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ctc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CTC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CTC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=57K:TERT-BUTYL+7-[(7-METHYL-1H-INDAZOL-5-YL)CARBONYL]-2,7-DIAZASPIRO[3.5]NONANE-2-CARBOXYLATE'>57K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ctc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ctc OCA], [https://pdbe.org/5ctc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ctc RCSB], [https://www.ebi.ac.uk/pdbsum/5ctc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ctc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACAC_YEAST ACAC_YEAST] Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole.<ref>PMID:6108218</ref> <ref>PMID:6103540</ref> <ref>PMID:8943372</ref> <ref>PMID:10757783</ref> <ref>PMID:12730220</ref>
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Authors: Vajdos, F.F.
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==See Also==
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*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
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Description: Humanized yeast ACC carboxyltransferase domain bound to {4-[3-(6,7-DIETHOXY-QUINAZOLIN-4-YLAMINO)-PHENYL]-THIAZOL-2-YL}-METHANOL
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Vajdos, F.F]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Vajdos FF]]

Current revision

Humanized yeast ACC carboxyltransferase domain bound to tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate

PDB ID 5ctc

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