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5eh2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence III== | |
| + | <StructureSection load='5eh2' size='340' side='right'caption='[[5eh2]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5eh2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EH2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eh2 OCA], [https://pdbe.org/5eh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eh2 RCSB], [https://www.ebi.ac.uk/pdbsum/5eh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eh2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Horton | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Cheng X]] |
| - | [[Category: | + | [[Category: Horton JR]] |
| - | [[Category: | + | [[Category: Patel A]] |
| + | [[Category: Wilson GG]] | ||
| + | [[Category: Zhang X]] | ||
Current revision
Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence III
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Categories: Homo sapiens | Large Structures | Cheng X | Horton JR | Patel A | Wilson GG | Zhang X
