5esd
From Proteopedia
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==Crystal Structure of M. tuberculosis MenD bound to ThDP and Mn2+== | ==Crystal Structure of M. tuberculosis MenD bound to ThDP and Mn2+== | ||
- | <StructureSection load='5esd' size='340' side='right' caption='[[5esd]], [[Resolution|resolution]] 2.25Å' scene=''> | + | <StructureSection load='5esd' size='340' side='right'caption='[[5esd]], [[Resolution|resolution]] 2.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[5esd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESD OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5esd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ESD FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr> |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5esd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esd OCA], [https://pdbe.org/5esd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5esd RCSB], [https://www.ebi.ac.uk/pdbsum/5esd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5esd ProSAT]</span></td></tr> | |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/MEND_MYCTU MEND_MYCTU] Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Large Structures]] |
- | [[Category: | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
- | [[Category: | + | [[Category: Baker EN]] |
- | [[Category: | + | [[Category: Bashiri G]] |
- | [[Category: | + | [[Category: Bulloch EMM]] |
- | [[Category: | + | [[Category: Jirgis ENM]] |
- | [[Category: | + | [[Category: Johnston JM]] |
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Current revision
Crystal Structure of M. tuberculosis MenD bound to ThDP and Mn2+
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