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5inj

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Crystal Structure of Prenyltransferase PriB Ternary Complex with L-Tryptophan and Dimethylallyl thiolodiphosphate (DMSPP)

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 ==Crystal Structure of Prenyltransferase PriB Ternary Complex with L-Tryptophan and Dimethylallyl thiolodiphosphate (DMSPP)==
-<StructureSection load='5inj' size='340' side='right' caption='[[5inj]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
+<StructureSection load='5inj' size='340' side='right'caption='[[5inj]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5inj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._rm-5-8 Streptomyces sp. rm-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5INJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5INJ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5inj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._RM-5-8 Streptomyces sp. RM-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5INJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5INJ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6C7:S-(3-METHYLBUT-2-EN-1-YL)+TRIHYDROGEN+THIODIPHOSPHATE'>6C7</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5inj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5inj OCA], [http://pdbe.org/5inj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5inj RCSB], [http://www.ebi.ac.uk/pdbsum/5inj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5inj ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DST:DIMETHYLALLYL+S-THIOLODIPHOSPHATE'>DST</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5inj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5inj OCA], [https://pdbe.org/5inj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5inj RCSB], [https://www.ebi.ac.uk/pdbsum/5inj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5inj ProSAT]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/A0A182DWE5_9ACTN A0A182DWE5_9ACTN]
-This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.
-Structure and specificity of a permissive bacterial C-prenyltransferase.,Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN Jr, Thorson JS, Singh S Nat Chem Biol. 2017 Feb 6. doi: 10.1038/nchembio.2285. PMID:28166207<ref>PMID:28166207</ref>
+==See Also==
+*[[Tryptophan synthase 3D structures|Tryptophan synthase 3D structures]]
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 5inj" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Streptomyces sp. rm-5-8]]
+[[Category: Large Structures]]
-[[Category: Benach, J]]
+[[Category: Streptomyces sp. RM-5-8]]
-[[Category: Cao, H]]
+[[Category: Benach J]]
-[[Category: Elshahawi, S]]
+[[Category: Cao H]]
-[[Category: Koss, J W]]
+[[Category: Elshahawi S]]
-[[Category: Morisco, L L]]
+[[Category: Koss JW]]
-[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis]]
+[[Category: Morisco LL]]
-[[Category: Phillips, G N]]
+[[Category: Phillips Jr GN]]
-[[Category: Thorson, J S]]
+[[Category: Thorson JS]]
-[[Category: Wasserman, S R]]
+[[Category: Wasserman SR]]
-[[Category: Abba family]]
-[[Category: Dmspp]]
-[[Category: Enzyme discovery for natural product biosynthesis]]
-[[Category: Indole-pt]]
-[[Category: Natpro]]
-[[Category: Prenyltransferase]]
-[[Category: PSI, Protein structure initiative]]
-[[Category: Pt fold]]
-[[Category: Structural genomic]]
-[[Category: Transferase]]
-[[Category: Tryptophan]]

5inj

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Crystal Structure of Prenyltransferase PriB Ternary Complex with L-Tryptophan and Dimethylallyl thiolodiphosphate (DMSPP)

Structural highlights

Function

See Also

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