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5inj

From Proteopedia

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<StructureSection load='5inj' size='340' side='right'caption='[[5inj]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='5inj' size='340' side='right'caption='[[5inj]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5inj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._rm-5-8 Streptomyces sp. rm-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5INJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5INJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5inj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._RM-5-8 Streptomyces sp. RM-5-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5INJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5INJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DST:DIMETHYLALLYL+S-THIOLODIPHOSPHATE'>DST</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5inj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5inj OCA], [http://pdbe.org/5inj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5inj RCSB], [http://www.ebi.ac.uk/pdbsum/5inj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5inj ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DST:DIMETHYLALLYL+S-THIOLODIPHOSPHATE'>DST</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5inj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5inj OCA], [https://pdbe.org/5inj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5inj RCSB], [https://www.ebi.ac.uk/pdbsum/5inj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5inj ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A182DWE5_9ACTN A0A182DWE5_9ACTN]
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This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.
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Structure and specificity of a permissive bacterial C-prenyltransferase.,Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN Jr, Thorson JS, Singh S Nat Chem Biol. 2017 Feb 6. doi: 10.1038/nchembio.2285. PMID:28166207<ref>PMID:28166207</ref>
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==See Also==
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*[[Tryptophan synthase 3D structures|Tryptophan synthase 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5inj" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Streptomyces sp. rm-5-8]]
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[[Category: Streptomyces sp. RM-5-8]]
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[[Category: Benach, J]]
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[[Category: Benach J]]
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[[Category: Cao, H]]
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[[Category: Cao H]]
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[[Category: Elshahawi, S]]
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[[Category: Elshahawi S]]
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[[Category: Koss, J W]]
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[[Category: Koss JW]]
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[[Category: Morisco, L L]]
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[[Category: Morisco LL]]
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[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis]]
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[[Category: Phillips Jr GN]]
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[[Category: Phillips, G N]]
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[[Category: Thorson JS]]
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[[Category: Thorson, J S]]
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[[Category: Wasserman SR]]
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[[Category: Wasserman, S R]]
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[[Category: Abba family]]
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[[Category: Dmspp]]
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[[Category: Enzyme discovery for natural product biosynthesis]]
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[[Category: Indole-pt]]
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[[Category: Natpro]]
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[[Category: Prenyltransferase]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Pt fold]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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[[Category: Tryptophan]]
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Current revision

Crystal Structure of Prenyltransferase PriB Ternary Complex with L-Tryptophan and Dimethylallyl thiolodiphosphate (DMSPP)

PDB ID 5inj

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OCA

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