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5kl8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Pumilio-Nos-CyclinB RNA complex== | |
| - | + | <StructureSection load='5kl8' size='340' side='right'caption='[[5kl8]], [[Resolution|resolution]] 4.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5kl8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KL8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kl8 OCA], [https://pdbe.org/5kl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kl8 RCSB], [https://www.ebi.ac.uk/pdbsum/5kl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kl8 ProSAT]</span></td></tr> |
| - | [[Category: Hall | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PUM_DROME PUM_DROME] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR and prevents its translation. Required for abdominal development and to support proliferation and self-renewal of germ cells. Pum is the only gene required for nos activity that is not also required for posterior localization of germline determinants. Pum is required during embryogenesis when nos activity apparently moves anteriorly from the posterior pole.<ref>PMID:1459455</ref> <ref>PMID:1576962</ref> <ref>PMID:9660969</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Drosophila melanogaster]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hall TMT]] | ||
| + | [[Category: Qiu C]] | ||
Current revision
Crystal structure of the Pumilio-Nos-CyclinB RNA complex
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