This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5kt4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5kt4" [edit=sysop:move=sysop])
Current revision (12:42, 6 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5kt4 is ON HOLD
+
==Teranry complex of human DNA polymerase iota R96G inserting dCMPNPP opposite template G in the presence of Mg2+==
 +
<StructureSection load='5kt4' size='340' side='right'caption='[[5kt4]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5kt4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KT4 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KX:2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]CYTIDINE'>0KX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kt4 OCA], [https://pdbe.org/5kt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kt4 RCSB], [https://www.ebi.ac.uk/pdbsum/5kt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kt4 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/POLI_HUMAN POLI_HUMAN] Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.<ref>PMID:11013228</ref> <ref>PMID:11251121</ref> <ref>PMID:11387224</ref> <ref>PMID:12410315</ref> <ref>PMID:14630940</ref> <ref>PMID:15199127</ref> <ref>PMID:15254543</ref>
-
Authors: Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
+
==See Also==
-
 
+
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
-
Description: Teranry complex of human DNA polymerase iota R96G inserting dCMPNPP opposite template G in the presence of Mg2+
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Lee, Y.S]]
+
__TOC__
-
[[Category: Guengerich, F.P]]
+
</StructureSection>
-
[[Category: Choi, J.Y]]
+
[[Category: Homo sapiens]]
-
[[Category: Yeom, M]]
+
[[Category: Large Structures]]
-
[[Category: Egli, M]]
+
[[Category: Synthetic construct]]
-
[[Category: Patra, A]]
+
[[Category: Choi JY]]
-
[[Category: Zhang, Q]]
+
[[Category: Egli M]]
 +
[[Category: Guengerich FP]]
 +
[[Category: Lee YS]]
 +
[[Category: Patra A]]
 +
[[Category: Yeom M]]
 +
[[Category: Zhang Q]]

Current revision

Teranry complex of human DNA polymerase iota R96G inserting dCMPNPP opposite template G in the presence of Mg2+

PDB ID 5kt4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5kt4"
Personal tools