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5kt7

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'''Unreleased structure'''
 
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The entry 5kt7 is ON HOLD
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==Teranry complex of human DNA polymerase iota(1-445) inserting dCMPNPP opposite template G in the presence of Mn2+==
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<StructureSection load='5kt7' size='340' side='right'caption='[[5kt7]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5kt7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KT7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.151&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KX:2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]CYTIDINE'>0KX</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kt7 OCA], [https://pdbe.org/5kt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kt7 RCSB], [https://www.ebi.ac.uk/pdbsum/5kt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kt7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POLI_HUMAN POLI_HUMAN] Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.<ref>PMID:11013228</ref> <ref>PMID:11251121</ref> <ref>PMID:11387224</ref> <ref>PMID:12410315</ref> <ref>PMID:14630940</ref> <ref>PMID:15199127</ref> <ref>PMID:15254543</ref>
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Authors: Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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Description: Teranry complex of human DNA polymerase iota(1-445) inserting dCMPNPP opposite template G in the presence of Mn2+
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Lee, Y.S]]
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__TOC__
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[[Category: Guengerich, F.P]]
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</StructureSection>
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[[Category: Choi, J.Y]]
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[[Category: Homo sapiens]]
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[[Category: Yeom, M]]
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[[Category: Large Structures]]
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[[Category: Egli, M]]
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[[Category: Synthetic construct]]
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[[Category: Patra, A]]
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[[Category: Choi JY]]
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[[Category: Zhang, Q]]
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[[Category: Egli M]]
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[[Category: Guengerich FP]]
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[[Category: Lee YS]]
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[[Category: Patra A]]
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[[Category: Yeom M]]
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[[Category: Zhang Q]]

Current revision

Teranry complex of human DNA polymerase iota(1-445) inserting dCMPNPP opposite template G in the presence of Mn2+

PDB ID 5kt7

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OCA

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