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5pwc

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PanDDA analysis group deposition -- Crystal Structure of SP100 in complex with E48115b

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Retrieved from "http://52.214.119.220/wiki/index.php/5pwc"

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 ==PanDDA analysis group deposition -- Crystal Structure of SP100 in complex with E48115b==
-<StructureSection load='5pwc' size='340' side='right' caption='[[5pwc]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
+<StructureSection load='5pwc' size='340' side='right'caption='[[5pwc]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5pwc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PWC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5pwc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PWC FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=W77:2,4-DICHLORO-N-(PYRIDIN-3-YL)BENZAMIDE'>W77</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.549&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pwc OCA], [http://pdbe.org/5pwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pwc RCSB], [http://www.ebi.ac.uk/pdbsum/5pwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pwc ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=W77:2,4-DICHLORO-N-(PYRIDIN-3-YL)BENZAMIDE'>W77</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5pwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pwc OCA], [https://pdbe.org/5pwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5pwc RCSB], [https://www.ebi.ac.uk/pdbsum/5pwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5pwc ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/SP100_HUMAN SP100_HUMAN]] Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.<ref>PMID:11909962</ref> <ref>PMID:14647468</ref> <ref>PMID:15247905</ref> <ref>PMID:15592518</ref> <ref>PMID:15767676</ref> <ref>PMID:16177824</ref> <ref>PMID:17245429</ref> <ref>PMID:21274506</ref> <ref>PMID:21880768</ref>
+[https://www.uniprot.org/uniprot/H0Y4R8_HUMAN H0Y4R8_HUMAN]
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Arrowsmith, C H]]
+[[Category: Homo sapiens]]
-[[Category: Bountra, C]]
+[[Category: Large Structures]]
-[[Category: Bradley, A R]]
+[[Category: Arrowsmith CH]]
-[[Category: Brandao-Neto, J]]
+[[Category: Bountra C]]
-[[Category: Brennan, P E]]
+[[Category: Bradley AR]]
-[[Category: Collins, P]]
+[[Category: Brandao-Neto J]]
-[[Category: Cox, O]]
+[[Category: Brennan PE]]
-[[Category: Delft, F von]]
+[[Category: Collins P]]
-[[Category: Dias, A]]
+[[Category: Cox O]]
-[[Category: Douangamath, A]]
+[[Category: Dias A]]
-[[Category: Edwards, A]]
+[[Category: Douangamath A]]
-[[Category: Fairhead, M]]
+[[Category: Edwards A]]
-[[Category: Krojer, T]]
+[[Category: Fairhead M]]
-[[Category: MacLean, E]]
+[[Category: Krojer T]]
-[[Category: Ng, J]]
+[[Category: MacLean E]]
-[[Category: Pearce, N M]]
+[[Category: Ng J]]
-[[Category: Renjie, Z]]
+[[Category: Pearce NM]]
-[[Category: Sethi, R]]
+[[Category: Renjie Z]]
-[[Category: Talon, R]]
+[[Category: Sethi R]]
-[[Category: Wright, N]]
+[[Category: Talon R]]
-[[Category: Bromodomain]]
+[[Category: Wright N]]
-[[Category: Epigenetic]]
+[[Category: Von Delft F]]
-[[Category: Pandda]]
-[[Category: Sgc - diamond i04-1 fragment screening]]
-[[Category: Transcription]]
-[[Category: Xchemexplorer]]

5pwc

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PanDDA analysis group deposition -- Crystal Structure of SP100 in complex with E48115b

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