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5s8w
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5s8w is ON HOLD Authors: Grosjean, H., Aimon, A., Hassel-Hart , S., Krojer, T., Talon, R., Douangamath, A., Koekemoer, L., Biggin, P.C., Spencer, J....) |
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative== | |
| + | <StructureSection load='5s8w' size='340' side='right'caption='[[5s8w]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5s8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5S8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5S8W FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y1D:N-(2,4-difluorophenyl)-4-(furan-2-carbonyl)piperazine-1-carboxamide'>Y1D</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5s8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5s8w OCA], [https://pdbe.org/5s8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5s8w RCSB], [https://www.ebi.ac.uk/pdbsum/5s8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5s8w ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Aimon | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Hassel-Hart | + | [[Category: Aimon A]] |
| - | [[Category: | + | [[Category: Biggin PC]] |
| - | [[Category: | + | [[Category: Douangamath A]] |
| - | [[Category: | + | [[Category: Grosjean H]] |
| - | [[Category: | + | [[Category: Hassel-Hart S]] |
| - | [[Category: | + | [[Category: Koekemoer L]] |
| + | [[Category: Krojer T]] | ||
| + | [[Category: Spencer J]] | ||
| + | [[Category: Talon R]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative
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Categories: Homo sapiens | Large Structures | Aimon A | Biggin PC | Douangamath A | Grosjean H | Hassel-Hart S | Koekemoer L | Krojer T | Spencer J | Talon R | Von Delft F
