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5t99

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Current revision (14:19, 6 March 2024) (edit) (undo)
 
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<StructureSection load='5t99' size='340' side='right'caption='[[5t99]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5t99' size='340' side='right'caption='[[5t99]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5t99]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_8492 Atcc 8492]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T99 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5t99]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_uniformis Bacteroides uniformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T99 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GIF:D-GALACTO-ISOFAGOMINE'>GIF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5t98|5t98]], [[5t9a|5t9a]], [[5t9g|5t9g]], [[5t9x|5t9x]], [[5ta0|5ta0]], [[5ta1|5ta1]], [[5ta5|5ta5]], [[5ta7|5ta7]], [[5ta9|5ta9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GIF:D-GALACTO-ISOFAGOMINE'>GIF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t99 OCA], [http://pdbe.org/5t99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t99 RCSB], [http://www.ebi.ac.uk/pdbsum/5t99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t99 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t99 OCA], [https://pdbe.org/5t99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t99 RCSB], [https://www.ebi.ac.uk/pdbsum/5t99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t99 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A2D0TCC8_BACUN A0A2D0TCC8_BACUN]
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In red algae, the most abundant principal cell wall polysaccharides are mixed galactan agars, of which agarose is a common component. While bioconversion of agarose is predominantly catalyzed by bacteria that live in the oceans, agarases have been discovered in microorganisms that inhabit diverse terrestrial ecosystems, including human intestines. Here we comprehensively define the structure-function relationship of the agarolytic pathway from the human intestinal bacterium Bacteroides uniformis (Bu) NP1. Using recombinant agarases from Bu NP1 to completely depolymerize agarose, we demonstrate that a non-agarolytic Bu strain can grow on GAL released from agarose. This relationship underscores that rare nutrient utilization by intestinal bacteria is facilitated by the acquisition of highly specific enzymes that unlock inaccessible carbohydrate resources contained within unusual polysaccharides. Intriguingly, the agarolytic pathway is differentially distributed throughout geographically distinct human microbiomes, reflecting a complex historical context for agarose consumption by human beings.
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Molecular basis of an agarose metabolic pathway acquired by a human intestinal symbiont.,Pluvinage B, Grondin JM, Amundsen C, Klassen L, Moote PE, Xiao Y, Thomas D, Pudlo NA, Anele A, Martens EC, Inglis GD, Uwiera RER, Boraston AB, Abbott DW Nat Commun. 2018 Mar 13;9(1):1043. doi: 10.1038/s41467-018-03366-x. PMID:29535379<ref>PMID:29535379</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5t99" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 8492]]
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[[Category: Bacteroides uniformis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Boraston, A B]]
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[[Category: Boraston AB]]
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[[Category: Pluvinage, B]]
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[[Category: Pluvinage B]]
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[[Category: Glycoside hydrolase]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of BuGH2Awt in complex with Galactoisofagomine

PDB ID 5t99

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