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5tbx

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==hnRNP A18 RNA Recognition Motif==
==hnRNP A18 RNA Recognition Motif==
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<StructureSection load='5tbx' size='340' side='right' caption='[[5tbx]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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<StructureSection load='5tbx' size='340' side='right'caption='[[5tbx]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5tbx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TBX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5tbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TBX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.767&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tbx OCA], [http://pdbe.org/5tbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tbx RCSB], [http://www.ebi.ac.uk/pdbsum/5tbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tbx ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tbx OCA], [https://pdbe.org/5tbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tbx RCSB], [https://www.ebi.ac.uk/pdbsum/5tbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tbx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CIRBP_HUMAN CIRBP_HUMAN]] Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.<ref>PMID:11574538</ref> <ref>PMID:16513844</ref>
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[https://www.uniprot.org/uniprot/CIRBP_HUMAN CIRBP_HUMAN] Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.<ref>PMID:11574538</ref> <ref>PMID:16513844</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The heterogeneous ribonucleoprotein A18 (hnRNP A18) is upregulated in hypoxic regions of various solid tumors and promotes tumor growth via the coordination of mRNA transcripts associated with pro-survival genes. Thus, hnRNP A18 represents an important therapeutic target in tumor cells. Presented here is the first X-ray crystal structure to be reported for the RNA-recognition motif of hnRNP A18. By comparing this structure with those of homologous RNA-binding proteins (i.e. hnRNP A1), three residues on one face of an antiparallel beta-sheet (Arg48, Phe50 and Phe52) and one residue in an unstructured loop (Arg41) were identified as likely to be involved in protein-nucleic acid interactions. This structure helps to serve as a foundation for biophysical studies of this RNA-binding protein and structure-based drug-design efforts for targeting hnRNP A18 in cancer, such as malignant melanoma, where hnRNP A18 levels are elevated and contribute to disease progression.
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Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif.,Coburn K, Melville Z, Aligholizadeh E, Roth BM, Varney KM, Carrier F, Pozharski E, Weber DJ Acta Crystallogr F Struct Biol Commun. 2017 Apr 1;73(Pt 4):209-214. doi:, 10.1107/S2053230X17003454. Epub 2017 Mar 22. PMID:28368279<ref>PMID:28368279</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5tbx" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aligholizadeh, E]]
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[[Category: Homo sapiens]]
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[[Category: Coburn, K M]]
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[[Category: Large Structures]]
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[[Category: Melville, Z]]
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[[Category: Aligholizadeh E]]
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[[Category: Roth, B M]]
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[[Category: Coburn KM]]
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[[Category: Varney, K M]]
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[[Category: Melville Z]]
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[[Category: Weber, D J]]
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[[Category: Roth BM]]
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[[Category: Rna binding protein]]
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[[Category: Varney KM]]
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[[Category: Rna-binding protein]]
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[[Category: Weber DJ]]

Current revision

hnRNP A18 RNA Recognition Motif

PDB ID 5tbx

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