This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5uqo
From Proteopedia
(Difference between revisions)
m (Protected "5uqo" [edit=sysop:move=sysop]) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatus== | |
| + | <StructureSection load='5uqo' size='340' side='right'caption='[[5uqo]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5uqo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UQO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uqo OCA], [https://pdbe.org/5uqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uqo RCSB], [https://www.ebi.ac.uk/pdbsum/5uqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uqo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRPC_ASPFM PRPC_ASPFM] Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. May play a role in virulence.<ref>PMID:16008561</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Citrate Synthase 3D structures|Citrate Synthase 3D structures]] | |
| - | + | *[[Methylcitrate synthase|Methylcitrate synthase]] | |
| - | [[Category: | + | == References == |
| - | [[Category: Chruszcz | + | <references/> |
| - | [[Category: Schlachter | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Aspergillus fumigatus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chruszcz M]] | ||
| + | [[Category: Schlachter C]] | ||
Current revision
Crystal structure of 2-methylcitrate synthase from Aspergillus fumigatus
| |||||||||||
