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5uqu
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==Crystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatus== | ==Crystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatus== | ||
| - | <StructureSection load='5uqu' size='340' side='right' caption='[[5uqu]], [[Resolution|resolution]] 1.70Å' scene=''> | + | <StructureSection load='5uqu' size='340' side='right'caption='[[5uqu]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5uqu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UQU OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5uqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UQU FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uqu OCA], [https://pdbe.org/5uqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uqu RCSB], [https://www.ebi.ac.uk/pdbsum/5uqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uqu ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PRPC_ASPFM PRPC_ASPFM] Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. May play a role in virulence.<ref>PMID:16008561</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Citrate Synthase 3D structures|Citrate Synthase 3D structures]] | ||
| + | *[[Methylcitrate synthase|Methylcitrate synthase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Chruszcz, M]] | ||
| - | [[Category: Schlachter, C]] | ||
| - | [[Category: 2-methylcitrate synthase]] | ||
[[Category: Aspergillus fumigatus]] | [[Category: Aspergillus fumigatus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chruszcz M]] |
| - | [[Category: | + | [[Category: Schlachter C]] |
Current revision
Crystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatus
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