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6v3z

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Current revision (14:35, 6 March 2024) (edit) (undo)
 
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<StructureSection load='6v3z' size='340' side='right'caption='[[6v3z]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6v3z' size='340' side='right'caption='[[6v3z]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6v3z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6V3Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6v3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Enteritidis Salmonella enterica subsp. enterica serovar Enteritidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V3Z FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6v3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3z OCA], [http://pdbe.org/6v3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v3z RCSB], [http://www.ebi.ac.uk/pdbsum/6v3z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3z ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v3z OCA], [https://pdbe.org/6v3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v3z RCSB], [https://www.ebi.ac.uk/pdbsum/6v3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v3z ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A1R2HMX1_SALEN A0A1R2HMX1_SALEN]
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Typhoid toxin is a virulence factor for the bacterial pathogen Salmonella Typhi, which causes typhoid fever in humans. After its synthesis by intracellular bacteria, typhoid toxin is secreted into the lumen of the Salmonella-containing vacuole by a secretion mechanism strictly dependent on TtsA, a specific muramidase that facilitates toxin transport through the peptidoglycan layer. Here we show that substrate recognition by TtsA depends on a discrete domain within its carboxy terminus, which targets the enzyme to the bacterial poles to recognize YcbB-edited peptidoglycan. Comparison of the atomic structures of TtsA bound to its substrate and that of a close homolog with different specificity identified specific determinants involved in substrate recognition. Combined with structure-guided mutagenesis and in vitro and in vivo crosslinking experiments, this study provides an unprecedented view of the mechanisms by which a muramidase recognizes its peptidoglycan substrate to facilitate protein secretion.
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Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase.,Geiger T, Lara-Tejero M, Xiong Y, Galan JE Elife. 2020 Jan 20;9. pii: 53473. doi: 10.7554/eLife.53473. PMID:31958059<ref>PMID:31958059</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6v3z" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Galan, J E]]
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[[Category: Salmonella enterica subsp. enterica serovar Enteritidis]]
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[[Category: Lara-Tejero, M]]
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[[Category: Galan JE]]
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[[Category: Muramidase lysozyme-like peptidoglycan-binding]]
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[[Category: Lara-Tejero M]]
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[[Category: Protein transport]]
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Current revision

Structure of Salmonella enteritidis Sen1395

PDB ID 6v3z

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