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6v4u

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'''Unreleased structure'''
 
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The entry 6v4u is ON HOLD until Paper Publication
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==Cryo-EM structure of SMCR8-C9orf72-WDR41 complex==
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<StructureSection load='6v4u' size='340' side='right'caption='[[6v4u]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6v4u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V4U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v4u OCA], [https://pdbe.org/6v4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v4u RCSB], [https://www.ebi.ac.uk/pdbsum/6v4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v4u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SMCR8_HUMAN SMCR8_HUMAN] Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:20562859, PubMed:27193190, PubMed:27103069, PubMed:27559131, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:20562859, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27617292, PubMed:28195531). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131, PubMed:28195531). In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes (PubMed:28195531).<ref>PMID:20562859</ref> <ref>PMID:27103069</ref> <ref>PMID:27193190</ref> <ref>PMID:27559131</ref> <ref>PMID:27617292</ref> <ref>PMID:28195531</ref>
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Authors:
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hurley JH]]
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[[Category: Su MY]]

Current revision

Cryo-EM structure of SMCR8-C9orf72-WDR41 complex

PDB ID 6v4u

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