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6v7u

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Current revision (14:36, 6 March 2024) (edit) (undo)
 
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<StructureSection load='6v7u' size='340' side='right'caption='[[6v7u]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
<StructureSection load='6v7u' size='340' side='right'caption='[[6v7u]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6v7u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteriophage_dms3 Bacteriophage dms3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V7U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6v7u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_virus_DMS3 Pseudomonas virus DMS3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V7U FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DMS3-3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=389469 Bacteriophage DMS3])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v7u OCA], [https://pdbe.org/6v7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v7u RCSB], [https://www.ebi.ac.uk/pdbsum/6v7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v7u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v7u OCA], [https://pdbe.org/6v7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v7u RCSB], [https://www.ebi.ac.uk/pdbsum/6v7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v7u ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0SML3_9CAUD A0SML3_9CAUD]
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The arms race between bacteria and phages has led to the evolution of diverse anti-phage defenses, several of which are controlled by quorum-sensing pathways. In this work, we characterize a quorum-sensing anti-activator protein, Aqs1, found in Pseudomonas phage DMS3. We show that Aqs1 inhibits LasR, the master regulator of quorum sensing, and present the crystal structure of the Aqs1-LasR complex. The 69-residue Aqs1 protein also inhibits PilB, the type IV pilus assembly ATPase protein, which blocks superinfection by phages that require the pilus for infection. This study highlights the remarkable ability of small phage proteins to bind multiple host proteins and disrupt key biological pathways. As quorum sensing influences various anti-phage defenses, Aqs1 provides a mechanism by which infecting phages might simultaneously dampen multiple defenses. Because quorum-sensing systems are broadly distributed across bacteria, this mechanism of phage counter-defense may play an important role in phage-host evolutionary dynamics.
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A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.,Shah M, Taylor VL, Bona D, Tsao Y, Stanley SY, Pimentel-Elardo SM, McCallum M, Bondy-Denomy J, Howell PL, Nodwell JR, Davidson AR, Moraes TF, Maxwell KL Mol Cell. 2021 Feb 4;81(3):571-583.e6. doi: 10.1016/j.molcel.2020.12.011. Epub, 2021 Jan 6. PMID:33412111<ref>PMID:33412111</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6v7u" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacteriophage dms3]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Maxwell, K L]]
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[[Category: Pseudomonas virus DMS3]]
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[[Category: Moraes, T F]]
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[[Category: Maxwell KL]]
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[[Category: Shah, M]]
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[[Category: Moraes TF]]
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[[Category: Prophage protein]]
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[[Category: Shah M]]
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[[Category: Viral protein]]
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Current revision

Structure of a phage-encoded quorum sensing anti-activator, Aqs1

PDB ID 6v7u

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