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6wlb

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Current revision (14:45, 6 March 2024) (edit) (undo)
 
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<StructureSection load='6wlb' size='340' side='right'caption='[[6wlb]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='6wlb' size='340' side='right'caption='[[6wlb]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6wlb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hybrid_aspen Hybrid aspen]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WLB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WLB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6wlb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Populus_tremula_x_Populus_tremuloides Populus tremula x Populus tremuloides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WLB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CesA3-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47664 Hybrid aspen])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PRD_900016:beta-cellopentaose'>PRD_900016</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_synthase_(UDP-forming) Cellulose synthase (UDP-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.12 2.4.1.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wlb OCA], [https://pdbe.org/6wlb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wlb RCSB], [https://www.ebi.ac.uk/pdbsum/6wlb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wlb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wlb OCA], [http://pdbe.org/6wlb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wlb RCSB], [http://www.ebi.ac.uk/pdbsum/6wlb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wlb ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6J8X0_POPPZ Q6J8X0_POPPZ]
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Cellulose is an essential plant cell wall component and represents the most abundant biopolymer on Earth. Supramolecular plant cellulose synthase complexes organize multiple linear glucose polymers into microfibrils as load-bearing wall components. We determined the structure of a poplar cellulose synthase CesA homotrimer that suggests a molecular basis for cellulose microfibril formation. This complex, stabilized by cytosolic plant conserved regions and helical exchange within the transmembrane segment, forms three channels occupied by nascent cellulose polymers. Secretion steers the polymers toward a common exit point, which may facilitate protofibril formation. CesAs' N-terminal domains assemble into a cytosolic stalk that interacts with a microtubule-tethering protein and may thus be involved in CesA localization. Our data suggest how cellulose synthase complexes assemble and provide the molecular basis for plant cell wall engineering.
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Architecture of a catalytically active homotrimeric plant cellulose synthase complex.,Purushotham P, Ho R, Zimmer J Science. 2020 Jul 9. pii: science.abb2978. doi: 10.1126/science.abb2978. PMID:32646917<ref>PMID:32646917</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6wlb" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hybrid aspen]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ho, R]]
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[[Category: Populus tremula x Populus tremuloides]]
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[[Category: Pallinti, P]]
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[[Category: Ho R]]
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[[Category: Zimmer, J]]
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[[Category: Pallinti P]]
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[[Category: Cell wall]]
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[[Category: Zimmer J]]
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[[Category: Cellulose]]
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[[Category: Glycosyltransferase]]
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[[Category: Membrane protein]]
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[[Category: Polysaccharide]]
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[[Category: Translocation]]
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Current revision

Structure of homotrimeric poplar cellulose synthase isoform 8

PDB ID 6wlb

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