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6wmi

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'''Unreleased structure'''
 
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The entry 6wmi is ON HOLD until Paper Publication
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==ZNF410 zinc fingers 1-5 with 17 mer blunt DNA Oligonucleotide==
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<StructureSection load='6wmi' size='340' side='right'caption='[[6wmi]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6wmi]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WMI FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wmi OCA], [https://pdbe.org/6wmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wmi RCSB], [https://www.ebi.ac.uk/pdbsum/6wmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wmi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZN410_HUMAN ZN410_HUMAN] Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416, PubMed:33301730). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416, PubMed:33301730). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286). May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215). However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33859416, PubMed:33301730).<ref>PMID:12370286</ref> <ref>PMID:30078215</ref> <ref>PMID:33301730</ref> <ref>PMID:33859416</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cheng X]]
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[[Category: Horton JR]]
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[[Category: Ren R]]

Current revision

ZNF410 zinc fingers 1-5 with 17 mer blunt DNA Oligonucleotide

PDB ID 6wmi

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